DICP OpenIR
Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring
Wang, Xin1; Zhou, Qinghua1; Jiang, Dandan1; Gong, Yulei2; Li, Enyou2; Li, Haiyang1
Source PublicationSCIENTIFIC REPORTS
2016-11-21
ISSN2045-2322
DOI10.1038/srep37525
Volume6
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; SOLID-PHASE EXTRACTION ; SENSITIVE DETECTION ; ONLINE MEASUREMENT ; WHOLE-BLOOD ; PHARMACOKINETICS ; REMIFENTANIL ; GLUCURONIDE ; EXPLOSIVES
AbstractThe plasma propofol concentration is important information for anaesthetists to monitor and adjust the anaesthesia depth for patients during a surgery operation. In this paper, a stand-alone ion mobility spectrometer (IMS) was constructed for the rapid measurement of the plasma propofol concentrations. Without any sample pre-treatment, the plasma samples were dropped on a piece of glass microfiber paper and then introduced into the IMS cell by the thermal desorption directly. Each individual measurement could be accomplished within 1 min. For the plasma propofol concentrations from 1 to 12 mu g mL(-1), the IMS response was linear with a correlation coefficient R-2 of 0.998, while the limit of detection was evaluated to be 0.1 mu g mL(-1). These measurement results did meet the clinical application requirements. Furthermore, other clinically-often-used drugs, including remifentanil, flurbiprofen and atracurium, were found no significant interference with the qualitative and quantitative analysis of the plasma propofol. The plasma propofol concentrations measured by IMS were correlated well with those measured by the high performance liquid chromatography (HPLC). The results confirmed an excellent agreement between these two methods. Finally, this method was applied to monitor the plasma propofol concentrations for a patient undergoing surgery, demonstrating its capability of anaesthesia monitoring in real clinical environments.
Language英语
WOS IDWOS:000388083100001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169739
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Haiyang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin 150001, Heilongjiang, Peoples R China
Recommended Citation
GB/T 7714
Wang, Xin,Zhou, Qinghua,Jiang, Dandan,et al. Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring[J]. SCIENTIFIC REPORTS,2016,6.
APA Wang, Xin,Zhou, Qinghua,Jiang, Dandan,Gong, Yulei,Li, Enyou,&Li, Haiyang.(2016).Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring.SCIENTIFIC REPORTS,6.
MLA Wang, Xin,et al."Ion mobility spectrometry as a simple and rapid method to measure the plasma propofol concentrations for intravenous anaesthesia monitoring".SCIENTIFIC REPORTS 6(2016).
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