DICP OpenIR
Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern
Guo, Hongtao1; Niu, Xuyan2; Gu, Yan3,4; Lu, Cheng2,5; Xiao, Cheng6,7; Yue, Kevin5; Zhang, Ge5; Pan, Xiaohua8; Jiang, Miao2; Tan, Yong2,5; Kong, Hongwei3; Liu, Zhenli9; Xu, Guowang3; Lu, Aiping2,5,10
KeywordRheumatoid Arthritis Traditional Chinese Medicine Cold Pattern Heat Pattern Metabolic Pathways
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2016-10-01
ISSN1422-0067
DOI10.3390/ijms17101757
Volume17Issue:10
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordMASS-SPECTROMETRY ; SYSTEMS BIOLOGY ; CARDIOVASCULAR RISK ; BIOMARKERS ; PLASMA ; METABONOMICS ; DISCOVERY ; DISEASE ; PROTEOMICS ; GENES
AbstractPattern classification is a key approach in Traditional Chinese Medicine (TCM), and it is used to classify the patients for intervention selection accordingly. TCM cold and heat patterns, two main patterns of rheumatoid arthritis (RA) had been explored with systems biology approaches. Different regulations of apoptosis were found to be involved in cold and heat classification in our previous works. For this study, the metabolic profiling of plasma was explored in RA patients with typical TCM cold or heat patterns by integrating liquid chromatography/mass spectrometry (LC/MS) and gas chromatography/mass spectrometry (GC/MS) platforms in conjunction with the Ingenuity Pathway Analysis (IPA) software. Three main processes of metabolism, including amino acid, carbohydrate and lipid were focused on for function analysis. The results showed that 29 and 19 differential metabolites were found in cold and heat patterns respectively, compared with healthy controls. The perturbation of amino acid metabolism (increased essential amino acids), carbohydrate metabolism (galactose metabolism) and lipid metabolism, were found to be involved in both cold and heat pattern RA. In particular, more metabolic perturbations in protein and collagen breakdown, decreased glycolytic activity and aerobic oxidation, and increased energy utilization associated with RA cold pattern patients. These findings may be useful for obtaining a better understanding of RA pathogenesis and for achieving a better efficacy in RA clinical practice.
Language英语
WOS IDWOS:000387768300019
PublisherMDPI AG
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169755
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu, Guowang; Lu, Aiping
Affiliation1.Henan Univ TCM, Affiliated Hosp 1, Dept Rheumatol, Zhengzhou 450000, Peoples R China
2.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Shanxi Datong Univ, Sch Med, Datong 037009, Peoples R China
5.Hong Kong Baptist Univ, Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Kowloon Tong 00852, Hong Kong, Peoples R China
6.China Japan Friendship Hosp, Dept Sci Res Adm, Beijing 100029, Peoples R China
7.People Hosp Yichun City, Dept Rheumatol, Yichun 336000, Peoples R China
8.Jinan Univ, Inst Biomed Guangzhou, Jinan Univ & Hong Kong Baptist Univ Joint Lab Inn, Guangzhou 510632, Guangdong, Peoples R China
9.China Acad Chinese Med Sci, Inst Basic Theory TCM, Beijing 100700, Peoples R China
10.Shanghai Municipal Educ Commiss, E Inst Chinese Tradit Internal Med, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Guo, Hongtao,Niu, Xuyan,Gu, Yan,et al. Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(10).
APA Guo, Hongtao.,Niu, Xuyan.,Gu, Yan.,Lu, Cheng.,Xiao, Cheng.,...&Lu, Aiping.(2016).Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(10).
MLA Guo, Hongtao,et al."Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.10(2016).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo, Hongtao]'s Articles
[Niu, Xuyan]'s Articles
[Gu, Yan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo, Hongtao]'s Articles
[Niu, Xuyan]'s Articles
[Gu, Yan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo, Hongtao]'s Articles
[Niu, Xuyan]'s Articles
[Gu, Yan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.