DICP OpenIR
A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors
Xu, Hui1,2; Li, Zhongyu1,2; Yu, Yue1,2; Sizdahkhani, Saman3; Ho, Winson S.3; Yin, Fangchao1,2; Wang, Li1; Zhu, Guoli1,2; Zhang, Min1; Jiang, Lei1; Zhuang, Zhengping3; Qin, Jianhua1
Source PublicationSCIENTIFIC REPORTS
2016-11-10
ISSN2045-2322
DOI10.1038/srep36670
Volume6
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordMICROVASCULAR ENDOTHELIAL-CELLS ; VITRO MODEL ; ELECTRICAL-RESISTANCE ; BBB ; CANCER ; CHIP ; RAT ; PERMEABILITY ; EXPRESSION ; SYSTEM
AbstractThe blood-brain barrier (BBB) restricts the uptake of many neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases. We proposed a new and dynamic in vivo-like three-dimensional microfluidic system that replicates the key structural, functional and mechanical properties of the blood-brain barrier in vivo. Multiple factors in this system work synergistically to accentuate BBB-specific attributes-permitting the analysis of complex organ-level responses in both normal and pathological microenvironments in brain tumors. The complex BBB microenvironment is reproduced in this system via physical cell-cell interaction, vascular mechanical cues and cell migration. This model possesses the unique capability to examine brain metastasis of human lung, breast and melanoma cells and their therapeutic responses to chemotherapy. The results suggest that the interactions between cancer cells and astrocytes in BBB microenvironment might affect the ability of malignant brain tumors to traverse between brain and vascular compartments. Furthermore, quantification of spatially resolved barrier functions exists within a single assay, providing a versatile and valuable platform for pharmaceutical development, drug testing and neuroscientific research.
Language英语
WOS IDWOS:000387510800001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169827
Collection中国科学院大连化学物理研究所
Corresponding AuthorQin, Jianhua
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Xu, Hui,Li, Zhongyu,Yu, Yue,et al. A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors[J]. SCIENTIFIC REPORTS,2016,6.
APA Xu, Hui.,Li, Zhongyu.,Yu, Yue.,Sizdahkhani, Saman.,Ho, Winson S..,...&Qin, Jianhua.(2016).A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors.SCIENTIFIC REPORTS,6.
MLA Xu, Hui,et al."A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors".SCIENTIFIC REPORTS 6(2016).
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