DICP OpenIR
Extensive characterization of peptides from Panax ginseng C. A. Meyer using mass spectrometric approach
Ye, Xueting1; Zhao, Nan2; Yu, Xi3; Han, Xiaoli1; Gao, Huiyuan1; Zhang, Xiaozhe2
KeywordGinseng Peptides Nano-lc-ms Ms Peaks Plant Proteomics Sequencing
Source PublicationPROTEOMICS
2016-11-01
ISSN1615-9853
DOI10.1002/pmic.201600183
Volume16Issue:21Pages:2788-2791
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordCELLS ; ROOT
AbstractPanax ginseng is an important herb that has clear effects on the treatment of diverse diseases. Until now, the natural peptide constitution of this herb remains unclear. Here, we conduct an extensive characterization of Ginseng peptidome using MS-based data mining and sequencing. The screen on the charge states of precursor ions indicated that Ginseng is a peptide-rich herb in comparison of a number of commonly used herbs. The Ginseng peptides were then extracted and submitted to nano-LC-MS/MS analysis using different fragmentation modes, including CID, high-energy collisional dissociation, and electron transfer dissociation. Further database search and de novo sequencing allowed the identification of total 308 peptides, some of which might have important biological activities. This study illustrates the abundance and sequences of endogenous Ginseng peptides, thus providing the information of more candidates for the screening of active compounds for future biological research and drug discovery studies.
Language英语
WOS IDWOS:000387168600007
PublisherWILEY-BLACKWELL
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169833
Collection中国科学院大连化学物理研究所
Corresponding AuthorGao, Huiyuan; Zhang, Xiaozhe
Affiliation1.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Wenhua Rd 103, Shenyang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biol Technol, Dalian, Peoples R China
3.Natl Univ Singapore, Food Sci & Technol Programme, Dept Chem, Singapore, Singapore
Recommended Citation
GB/T 7714
Ye, Xueting,Zhao, Nan,Yu, Xi,et al. Extensive characterization of peptides from Panax ginseng C. A. Meyer using mass spectrometric approach[J]. PROTEOMICS,2016,16(21):2788-2791.
APA Ye, Xueting,Zhao, Nan,Yu, Xi,Han, Xiaoli,Gao, Huiyuan,&Zhang, Xiaozhe.(2016).Extensive characterization of peptides from Panax ginseng C. A. Meyer using mass spectrometric approach.PROTEOMICS,16(21),2788-2791.
MLA Ye, Xueting,et al."Extensive characterization of peptides from Panax ginseng C. A. Meyer using mass spectrometric approach".PROTEOMICS 16.21(2016):2788-2791.
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