DICP OpenIR
An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103
Zheng, Huizhen1,3; Gao, Meng1,3; Ren, Ying1,3; Lou, Ruyun1,3; Xie, Hongguo1; Yu, Weiting1; Liu, Xiudong2; Ma, Xiaojun1
KeywordHydrogel Edta-ca-alg Ph-responsive Carrier Lactobacillus Rhamnosus Atcc 53103 Controlled Release
Source PublicationCARBOHYDRATE POLYMERS
2017-01-02
ISSN0144-8617
DOI10.1016/j.carbpol.2016.08.096
Volume155Pages:329-335
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS Research AreaChemistry ; Polymer Science
WOS KeywordMICROENCAPSULATION ; PROBIOTICS ; ENCAPSULATION ; BACTERIA ; CHITOSAN ; GELATION
AbstractA pH-responsive carrier based on an ethylenediaminetetraacetic-calcium-alginate (EDTA-Ca-Alg) system was developed by controlling the release of Ca2+. The system remained in the solution state at neutral pH since EDTA completely chelated the Ca2+. In contrast, a hydrogel immediately formed when the pH was below 4.0, which triggered the in situ release of Ca2+ from the EDTA-Ca compound and led to alginate-Ca binding. Taking advantage of the pH sensitivity, we prepared hydrogel microspheres with uniform size to entrap Lactobacillus rhamnosus ATCC 53103 through emulsification. In an acidic environment, the hydrogel structure remained compact with, negligible pores to protect L. rhamnosus ATCC 53103. However, in a neutral intestinal environment, the hydrogel structure gradually disassembled because of the Ca2+ release from the hydrogel, which caused cell release. Therefore, a pH-responsive carrier was developed for the protection and the controlled release of cells in gastrointestinal tract, thus providing potential for oral delivery of probiotics. (C) 2016 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000386402600035
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169965
Collection中国科学院大连化学物理研究所
Corresponding AuthorYu, Weiting; Liu, Xiudong
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Huizhen,Gao, Meng,Ren, Ying,et al. An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103[J]. CARBOHYDRATE POLYMERS,2017,155:329-335.
APA Zheng, Huizhen.,Gao, Meng.,Ren, Ying.,Lou, Ruyun.,Xie, Hongguo.,...&Ma, Xiaojun.(2017).An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103.CARBOHYDRATE POLYMERS,155,329-335.
MLA Zheng, Huizhen,et al."An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103".CARBOHYDRATE POLYMERS 155(2017):329-335.
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