DICP OpenIR
A crucial role for spatial distribution in bacterial quorum sensing
Gao, Meng1,2; Zheng, Huizhen1,2; Ren, Ying1,2; Lou, Ruyun1,2; Wu, Fan1,2; Yu, Weiting1; Liu, Xiudong3; Ma, Xiaojun1
Source PublicationSCIENTIFIC REPORTS
2016-10-04
ISSN2045-2322
DOI10.1038/srep34695
Volume6
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordESCHERICHIA-COLI ; VIBRIO-HARVEYI ; CELL MICROENCAPSULATION ; BIOFILM FORMATION ; MICROCAPSULES ; DIFFUSION ; ALGINATE ; COMMUNICATION ; AGGREGATION ; EXPRESSION
AbstractQuorum sensing (QS) is a process that enables bacteria to communicate using secreted signaling molecules, and then makes a population of bacteria to regulate gene expression collectively and control behavior on a community-wide scale. Theoretical studies of efficiency sensing have suggested that both mass-transfer performance in the local environment and the spatial distribution of cells are key factors affecting QS. Here, an experimental model based on hydrogel microcapsules with a three-dimensional structure was established to investigate the influence of the spatial distribution of cells on bacterial QS. Vibrio harveyi cells formed different spatial distributions in the microcapsules, i.e., they formed cell aggregates with different structures and sizes. The cell aggregates displayed stronger QS than did unaggregated cells even when equal numbers of cells were present. Large aggregates (LA) of cells, with a size of approximately 25 mu m, restricted many more autoinducers (AIs) than did small aggregates (SA), with a size of approximately 10 mu m, thus demonstrating that aggregate size significantly affects QS. These findings provide a powerful demonstration of the fact that the spatial distribution of cells plays a crucial role in bacterial QS.
Language英语
WOS IDWOS:000384711300002
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/169999
Collection中国科学院大连化学物理研究所
Corresponding AuthorYu, Weiting; Liu, Xiudong
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China
Recommended Citation
GB/T 7714
Gao, Meng,Zheng, Huizhen,Ren, Ying,et al. A crucial role for spatial distribution in bacterial quorum sensing[J]. SCIENTIFIC REPORTS,2016,6.
APA Gao, Meng.,Zheng, Huizhen.,Ren, Ying.,Lou, Ruyun.,Wu, Fan.,...&Ma, Xiaojun.(2016).A crucial role for spatial distribution in bacterial quorum sensing.SCIENTIFIC REPORTS,6.
MLA Gao, Meng,et al."A crucial role for spatial distribution in bacterial quorum sensing".SCIENTIFIC REPORTS 6(2016).
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