DICP OpenIR
Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules
Zheng, Huizhen1,2; Gao, Meng1,2; Ren, Ying1,2; Lou, Ruyun1,2; Xie, Hongguo1; Yu, Weiting1; Liu, Xiudong3; Ma, Xiaojun1
KeywordAlginate-chitosan Microcapsule Gel Structure Protonated Amino Cell Adhesion And Spreading Surface Property
Source PublicationACS APPLIED MATERIALS & INTERFACES
2016-08-03
ISSN1944-8244
DOI10.1021/acsami.6b05778
Volume8Issue:30Pages:19333-19342
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS KeywordALGINATE-BASED MICROCAPSULES ; PANCREATIC-ISLETS ; CHITOSAN ; BIOCOMPATIBILITY ; ENCAPSULATION ; MICROSPHERES ; TISSUE
AbstractThe surface properties of implanted materials or devices play critical roles in modulating cell behavior. However, the surface properties usually affect cell behaviors synergetically so that it is, still difficult to separately investigate the influence of a single property on cell behavior in practical applications. In this study, alginate chitosan (AC) microcapsules with a dense or loose gel structure were fabricated to understand the effect of gel structure on cell behavior. Cells preferentially adhered and spread on the loose gel structure microcapsules-rather than on the dense ones. The two types of microcapsules exhibited nearly identical surface positive charges, roughness, stiffness, and hydrophilicity; thus, the result suggested that the gel structure was the principal factor affecting cell behavior. X-ray photoelectron spectroscopy analyses demonstrated that the overall percentage Of positively charged amino groups was similar on both microcapsules. The different gel structures led to different states and distributions of the, positively charged amino groups of chitosan, so we conclude that the loose gel structure facilitated greater cell adhesion and spreading mainly because more protonated amino groups remained unbound and exposed on the surface of these microcapsules.
Language英语
WOS IDWOS:000380968300018
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170087
Collection中国科学院大连化学物理研究所
Corresponding AuthorYu, Weiting; Liu, Xiudong
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Huizhen,Gao, Meng,Ren, Ying,et al. Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(30):19333-19342.
APA Zheng, Huizhen.,Gao, Meng.,Ren, Ying.,Lou, Ruyun.,Xie, Hongguo.,...&Ma, Xiaojun.(2016).Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules.ACS APPLIED MATERIALS & INTERFACES,8(30),19333-19342.
MLA Zheng, Huizhen,et al."Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules".ACS APPLIED MATERIALS & INTERFACES 8.30(2016):19333-19342.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng, Huizhen]'s Articles
[Gao, Meng]'s Articles
[Ren, Ying]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng, Huizhen]'s Articles
[Gao, Meng]'s Articles
[Ren, Ying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng, Huizhen]'s Articles
[Gao, Meng]'s Articles
[Ren, Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.