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High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis
Wang, Yan1,2; Jiang, Jichun1,2; Hua, Lei1; Hou, Keyong1; Xie, Yuanyuan1; Chen, Ping1; Liu, Wei1,2; Li, Qingyun3; Wang, Shuang1,2; Li, Haiyang1
Source PublicationANALYTICAL CHEMISTRY
2016-09-20
ISSN0003-2700
DOI10.1021/acs.analchem.6b01707
Volume88Issue:18Pages:9047-9055
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordFLIGHT-MASS-SPECTROMETRY ; VOLATILE ORGANIC-COMPOUNDS ; COLLISION-INDUCED DISSOCIATION ; VACUUM-ULTRAVIOLET LAMP ; EXHALED BREATH ; GAS-ANALYSIS ; ION FUNNEL ; CHEMICAL-IONIZATION ; MOLECULAR-IONS ; BIOMARKERS
AbstractPhoton ionization mass spectrometry (PI-MS) is a widely used technique for the online detection of trace substances to complex matrices. In this:work, a new high-pressure photon ionization (HPPI) ion source based on a vacuum ultraviolet (VUV) Kr lamp was developed for time-of-flight mass spectrometry (TOFMS). The detection sensitivity was improved by elevating thee ion source pressure to about 700 Pa. A radio frequency (RF)-only quadrupole was employed as the ion guide system following the HPPI source to: achieve high ion transmission efficiency. In-source collision induced dissociation (CID) was conducted for accurate chemical identification by varying the voltage between the ion source and the ion guide. The high humidity of the breath air can promote-the-detection of some compounds with higher ionization potentials (IPs) that could not be well detected by Single photon. ionization (SPI) at low pressure. Under 100%, relative humidity (37 degrees C), the limits of detection down to 0.015 ppbv (parts per billion by volume) for aliphatic and aromatic hydrocarbons were obtained. This HPPI-TOFMS system was preliminarily applied for online investigations of the exhaled breath from both healthy nonsmoker and smoker subjects, demonstrating its analytical capacity for complicated gases analysis. Subsequently, several frequently reported VOCs in the breath of healthy volunteers, i.e, acetone, isoprene, 2-butanone, ethanol, acetic acid, and isopropanol, were successfully identified and quantified.
Language英语
WOS IDWOS:000384038400018
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170169
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Haiyang
Affiliation1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100039, Peoples R China
3.Jilin Univ, Dept Instrumentat & Elect Engn, Changchun 130021, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yan,Jiang, Jichun,Hua, Lei,et al. High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis[J]. ANALYTICAL CHEMISTRY,2016,88(18):9047-9055.
APA Wang, Yan.,Jiang, Jichun.,Hua, Lei.,Hou, Keyong.,Xie, Yuanyuan.,...&Li, Haiyang.(2016).High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis.ANALYTICAL CHEMISTRY,88(18),9047-9055.
MLA Wang, Yan,et al."High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis".ANALYTICAL CHEMISTRY 88.18(2016):9047-9055.
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