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Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry
Fu, Yanqing1,4; Zhou, Zhihui1,4; Kong, Hongwei1,4; Lu, Xin1,4; Zhao, Xinjie1,4; Chen, Yihui2; Chen, Jia3; Wu, Zeming5; Xu, Zhiliang3; Zhao, Chunxia1,4; Xu, Guowang1,4
Source PublicationANALYTICAL CHEMISTRY
2016-09-06
ISSN0003-2700
DOI10.1021/acs.analchem.6b02482
Volume88Issue:17Pages:8870-8877
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordMS-BASED METABOLOMICS ; MULTIRESIDUE ANALYSIS ; ORGANIC CONTAMINANTS ; ANTIBIOTIC-RESIDUES ; VETERINARY DRUGS ; QUECHERS METHOD ; LC-MS/MS ; FOOD ; ORBITRAP ; IDENTIFICATION
AbstractIdentification of illegal additives in complex matrixes is important in the food safety field. In this study a nontargeted screening strategy was developed to find illegal additives based on ultrahigh-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS). First, an analytical method for possible illegal additives in complex matrixes was established including fast sample pretreatment, accurate UHPLC separation, and HRMS detection. Second, efficient data processing and differential analysis workflow were suggested and applied to find potential risk compounds. Third, structure elucidation of risk compounds was performed by (1) searching online databases [Metlin and the Human Metabolome Database (HMDB)] and an in-house database which was established at the above-defined conditions of UHPLC-HRMS analysis and contains information on retention time, mass spectra (MS), and tandem mass spectra (MS/MS) of 475 illegal additives, (2) analyzing fragment ions, and (3) referring to fragmentation rules. Fish was taken as an example to show the usefulness of the nontargeted screening strategy, and six additives were found in suspected fish samples. Quantitative analysis was further carried out to determine the contents of these compounds. The satisfactory application of this strategy in fish samples means that it can also be used in the screening of illegal additives in other kinds of food samples.
Language英语
WOS IDWOS:000382805900073
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170203
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhao, Chunxia; Xu, Guowang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Xiangshan Entry Exit Inspect & Quarantine Bur, Ningbo 315000, Zhejiang, Peoples R China
3.Hangzhou Pooke Testing Technol Co Ltd, Hangzhou 310000, Zhejiang, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Thermo Fisher Sci, Applicat Ctr, Shanghai 210623, Peoples R China
Recommended Citation
GB/T 7714
Fu, Yanqing,Zhou, Zhihui,Kong, Hongwei,et al. Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry[J]. ANALYTICAL CHEMISTRY,2016,88(17):8870-8877.
APA Fu, Yanqing.,Zhou, Zhihui.,Kong, Hongwei.,Lu, Xin.,Zhao, Xinjie.,...&Xu, Guowang.(2016).Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry.ANALYTICAL CHEMISTRY,88(17),8870-8877.
MLA Fu, Yanqing,et al."Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry".ANALYTICAL CHEMISTRY 88.17(2016):8870-8877.
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