DICP OpenIR
Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells
Zhao, Ning1; Liu, Siyu1; Jiang, Qike2; Lan, Tian1; Cheng, Zhen3; Liu, Hongguang1
KeywordAffibody Her2 Fluorescent Imaging One-pot Synthesis Quantum Dots
Source PublicationCHEMBIOCHEM
2016-07-01
ISSN1439-4227
DOI10.1002/cbic.201600219
Volume17Issue:13Pages:1202-1206
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS KeywordQUANTUM DOTS ; BREAST-CANCER ; ANTI-HER2 ANTIBODY ; IN-VIVO ; NANOPARTICLES ; TUMORS ; HER2 ; LUNG ; PET
AbstractRecently, semiconductor nanoparticles such as quantum dots (QDs) have attracted significant attention for bioimaging. Complex chemical functionalization, surface modification, and bioconjugation chemistry are generally required to tag biomolecules to QDs for imaging of different biomarkers. In this study, we report a simple method for production of QDs stabilized by the small protein, Affibody (AF-QDs) for fluorescent imaging of the human epidermal growth factor receptor type2 (HER2) in human A549 lung cancer cells. This one-pot synthesis of AF-QDs avoids complex chemical conjugation procedures and demonstrates a promising approach for the preparation of fluorescent nanoprobes for imaging of cancer targets.
Language英语
WOS IDWOS:000379826400003
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170367
Collection中国科学院大连化学物理研究所
Corresponding AuthorCheng, Zhen; Liu, Hongguang
Affiliation1.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, 195 Chuangxin Rd, Shenyang 110000, Japan
2.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, 1201 Welch Rd, Stanford, CA 94040 USA
Recommended Citation
GB/T 7714
Zhao, Ning,Liu, Siyu,Jiang, Qike,et al. Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells[J]. CHEMBIOCHEM,2016,17(13):1202-1206.
APA Zhao, Ning,Liu, Siyu,Jiang, Qike,Lan, Tian,Cheng, Zhen,&Liu, Hongguang.(2016).Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells.CHEMBIOCHEM,17(13),1202-1206.
MLA Zhao, Ning,et al."Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells".CHEMBIOCHEM 17.13(2016):1202-1206.
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