DICP OpenIR
Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells
Liu, Yang1; Wang, Shujun2,3; Sun, Dongsheng1,3; Liu, Yongdong4; Liu, Yang1; Wang, Yang1,5; Liu, Chang1,6; Wu, Hao1,3; Lv, Yan2,3; Ren, Ying2,3; Guo, Xin2; Sun, Guangwei1; Ma, Xiaojun2
Source PublicationSCIENTIFIC REPORTS
2016-07-19
ISSN2045-2322
DOI10.1038/srep29858
Volume6
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordALGINATE GEL BEADS ; MATRIX METALLOPROTEINASES ; PLASMINOGEN-ACTIVATOR ; BREAST-CANCER ; INCREASED EXPRESSION ; MODEL ; UROKINASE ; CARCINOMA ; CULTURE ; TISSUE
AbstractTumor metastasis with resistance to anticancer therapies is the main cause of death in cancer patients. It is necessary to develop reliable tumor metastasis models that can closely recapitulate the pathophysiological features of the native tumor tissue. In this study, chondroitin sulfate (CS)-modified alginate hydrogel beads (ALG-CS) are developed to mimic the in vivo tumor microenvironment with an abnormally increased expression of CS for the promotion of tumor cell metastasis. The modification mechanism of CS on alginate hydrogel is due to the cross-linking between CS and alginate molecules via coordination of calcium ions, which enables ALG-CS to possess significantly different physical characteristics than the traditional alginate beads (ALG). And quantum chemistry calculations show that in addition to the traditional egg-box structure, novel asymmetric egg-box-like structures based on the interaction between these two kinds of polymers are also formed within ALG-CS. Moreover, tumor cell metastasis is significantly enhanced in ALG-CS compared with that in ALG, as confirmed by the increased expression of MMP genes and proteins and greater in vitro invasion ability. Therefore, ALG-CS could be a convenient and effective 3D biomimetic scaffold that would be used to construct standardized tumor metastasis models for tumor research and anticancer drug screening.
Language英语
WOS IDWOS:000379877300001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170413
Collection中国科学院大连化学物理研究所
Corresponding AuthorSun, Guangwei
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
5.Dalian Univ, Sch Life Sci, Dalian 116023, Peoples R China
6.Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yang,Wang, Shujun,Sun, Dongsheng,et al. Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells[J]. SCIENTIFIC REPORTS,2016,6.
APA Liu, Yang.,Wang, Shujun.,Sun, Dongsheng.,Liu, Yongdong.,Liu, Yang.,...&Ma, Xiaojun.(2016).Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells.SCIENTIFIC REPORTS,6.
MLA Liu, Yang,et al."Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells".SCIENTIFIC REPORTS 6(2016).
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