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Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry
Luo, Ping1; Yu, Haoyong2; Zhao, Xinjie1; Bao, Yuqian2; Hong, Christopher S.3; Zhang, Pin4; Tu, Yinfang2; Yin, Peiyuan1; Gao, Peng1; Wei, Li2; Zhuang, Zhengping3; Jia, Weiping2; Xu, Guowang1
KeywordMetabolomics Metabolic Profiling Roux-en-y Gastric Bypass Rygb Diabetes
Source PublicationJOURNAL OF PROTEOME RESEARCH
2016-04-01
ISSN1535-3893
DOI10.1021/acs.jproteome.6b00022
Volume15Issue:4Pages:1288-1299
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordSTEAROYL-COA DESATURASE ; CHAIN AMINO-ACIDS ; INSULIN-RESISTANCE ; BARIATRIC SURGERY ; SKELETAL-MUSCLE ; SERUM METABOLOMICS ; BETA-OXIDATION ; OBESE-PATIENTS ; BILE-ACIDS ; INFLAMMATION
AbstractRoux-en-Y gastric bypass (RYGB) is one of the most effective treatments for long-term weight loss and diabetes remission; however, the mechanisms underlying these changes are not clearly understood. In this study, the serum metabolic profiles of 23 remission and 12 nonremission patients with type 2 diabetes mellitus (T2DM) were measured at baseline, 6- and 12-months after RYGB. A metabolomics analysis was performed based on ultra-performance liquid chromatography mass spectrometry. Clinical improvements in insulin sensitivity, energy metabolism, and inflammation were related to metabolic alterations of free fatty acids (FFAs), acylcarnitines, amino acids, bile acids, and lipids species. Differential metabolic profiles were observed between the two T2DM subgroups, and patients with severity fat accumulation and oxidation stress may be more suitable for RYGB. Baseline levels of tryptophan, bilirubin, and indoxyl sulfate measured prior to surgery as well as levels of FFA 16:0, FFA 18:3, FFA 17:2, and hippuric acid measured at 6 months after surgery best predicted the suitability and efficacy of RYGB for patients with T2DM. These metabolites represent potential biomarkers that may be clinically helpful in individualized treatment for T2DM patients by RYGB.
Language英语
WOS IDWOS:000373519900018
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170685
Collection中国科学院大连化学物理研究所
Corresponding AuthorJia, Weiping; Xu, Guowang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus,Shanghai Diabet, Dept Endocrinol & Metab,Shanghai Clin Ctr Diabet, Yishan Rd 600, Shanghai 200233, Peoples R China
3.NINDS, NIH, Surg Neurol Branch, Bethesda, MD 20892 USA
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Gen Surg, Yishan Rd, Shanghai 200233, Peoples R China
Recommended Citation
GB/T 7714
Luo, Ping,Yu, Haoyong,Zhao, Xinjie,et al. Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2016,15(4):1288-1299.
APA Luo, Ping.,Yu, Haoyong.,Zhao, Xinjie.,Bao, Yuqian.,Hong, Christopher S..,...&Xu, Guowang.(2016).Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,15(4),1288-1299.
MLA Luo, Ping,et al."Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 15.4(2016):1288-1299.
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