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Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography
Szwed, Kamila; Ou, Junjie; Huang, Guang; Lin, Hui; Liu, Zhongshan; Wang, Hongwei; Zou, Hanfa
KeywordCapillary Liquid Chromatography Cyclodextrins Enantioseparation
Source PublicationJOURNAL OF SEPARATION SCIENCE
2016-03-01
ISSN1615-9306
DOI10.1002/jssc.201501157
Volume39Issue:6Pages:1110-1117
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordPOLYHEDRAL OLIGOMERIC SILSESQUIOXANES ; RING-OPENING POLYMERIZATION ; ONE-POT APPROACH ; BETA-CYCLODEXTRIN ; STATIONARY PHASES ; CHIRAL SEPARATIONS ; FUNCTIONAL MONOMER ; FACILE PREPARATION ; ELECTROCHROMATOGRAPHY ; ELECTROPHORESIS
AbstractCyclodextrins and their derivatives are one of the most common and successful chiral selectors. However, there have been few publications about the use of cyclodextrin-modified monoliths. In this study, organic hybrid monoliths were prepared by the immobilization of derivatized -cyclodextrin alone or with l-2-allylglycine hydrochloride to the polyhedral oligomeric silsesquioxane methacryl substituted monolith. The main topic of this study is a combined system with dual chiral selectors (l-2-allylglycine hydrochloride and -cyclodextrin) as monolithic chiral stationary phase. The effect of l-2-allylglycine hydrochloride concentration on enantioseparation was investigated. The enantioseparation of the four acidic compounds with resolutions up to 2.87 was achieved within 2.5 min on the prepared chiral monolithic column in capillary liquid chromatography. Moreover, the possible mechanism of enantioseparation was discussed.
Language英语
WOS IDWOS:000373617100011
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170695
Collection中国科学院大连化学物理研究所
Corresponding AuthorOu, Junjie; Zou, Hanfa
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Szwed, Kamila,Ou, Junjie,Huang, Guang,et al. Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(6):1110-1117.
APA Szwed, Kamila.,Ou, Junjie.,Huang, Guang.,Lin, Hui.,Liu, Zhongshan.,...&Zou, Hanfa.(2016).Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography.JOURNAL OF SEPARATION SCIENCE,39(6),1110-1117.
MLA Szwed, Kamila,et al."Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography".JOURNAL OF SEPARATION SCIENCE 39.6(2016):1110-1117.
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