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Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts
Wang, Zhixin1; Qu, Yang1; Wang, Li1; Zhang, Xiaozhe1; Xiao, Hongbin2
KeywordFragment Ions Linear Ion Trap-orbitrap Stellera Chamaejasme Traditional Chinese Medicine Ultra-high Performance Liquid Chromatography
Source PublicationJOURNAL OF SEPARATION SCIENCE
2016-04-01
ISSN1615-9306
DOI10.1002/jssc.201500981
Volume39Issue:7Pages:1379-1388
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordDAPHNANE-TYPE DITERPENOIDS ; WIKSTROEMIA-RETUSA ; ROOTS ; IDENTIFICATION ; CONSTITUENTS ; L. ; COMPOUND
AbstractStellera chamaejasme, a famous toxic herb, has been used in traditional Chinese medicine to treat various diseases. For decades, increasing attention inmodern pharmacological studies has been drawn to S. chamaejasme because of its potential anti-tumor, anti-virus, and anti-fungus activities. However, due to the intrinsic complexity of chemical constitutes, hardly any investigations formed an overall recognition for the chemical profiles of this herb. In this study, a rapid and sensitive ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry method was developed to characterize the chemical components of S. chamaejasme extracts. Based on optimized ultra-high performance liquid chromatography and mass spectrometry conditions and systematic fragment ions-based strategy, a total of 47 components including flavones, diterpenes, coumarins, and lignans were simultaneously detected and identified or tentatively identified for the first time. The MSn fragmentation patterns of all the characterized compounds in positive or negative electrospray ionization modes were also explored and summarized. These results provided essential data for further pharmacological research on S. chamaejasme. Moreover, the method was demonstrated to be an efficient tool for rapid qualitative analysis of secondary metabolites from natural resources.
Language英语
WOS IDWOS:000374029500022
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170727
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Xiaozhe
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
2.Beijing Univ Chinese Med, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Zhixin,Qu, Yang,Wang, Li,et al. Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(7):1379-1388.
APA Wang, Zhixin,Qu, Yang,Wang, Li,Zhang, Xiaozhe,&Xiao, Hongbin.(2016).Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts.JOURNAL OF SEPARATION SCIENCE,39(7),1379-1388.
MLA Wang, Zhixin,et al."Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts".JOURNAL OF SEPARATION SCIENCE 39.7(2016):1379-1388.
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