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Metabonomic study of rats exposed to cigarette sidestream smoke
Lian Wen-liu1,2; Shi Xian-zhe3; Luo Jia2; Ren Feng-lian1
KeywordMetabonomics Rats Urine Endogenous Metabolites Exogenous Metabolites
Source PublicationJOURNAL OF CENTRAL SOUTH UNIVERSITY
2016-03-01
ISSN2095-2899
DOI10.1007/s11771-016-3100-6
Volume23Issue:3Pages:535-543
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
WOS SubjectMetallurgy & Metallurgical Engineering
WOS Research AreaMetallurgy & Metallurgical Engineering
WOS KeywordPOLYCYCLIC AROMATIC-HYDROCARBONS ; ENVIRONMENTAL TOBACCO-SMOKE ; LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; ADULT SMOKERS ; L-DOPA ; URINE ; BIOMARKERS ; CANCER ; OPPORTUNITIES
AbstractA metabonomic approach was undertaken in order to detect urinary endogenous and exogenous metabolites and to evaluate the effects of passive exposure to cigarette sidestream smoke on rats. Urinary samples from three groups of rats were determined including control rats, rats treated with blended cigarettes (nonmenthol cigarettes) and rats treated with menthol cigarettes. The total urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), total 1-hydroxypyrene (1-HOP) and 3-hydroxybenzo[a] pyrene (3-HOBaP) were determined for assessing exposure to cigarette sidestream smoke toxins. Urinary endogenous metabolites in the three groups of rats were also analyzed and the data were processed by chemometrics. Eleven endogenous metabolites were found and identified. Their relative levels were compared among the three groups. The results show that cigarette sidestream smoke has complex effect on rats. Blended cigarette group makes difference to menthol cigarette group in the rats' urinary metabolic changes. Menthol adding to cigarettes has positive and negative effects on rats, respectively. The urinary metabolic profiling of menthol cigarette group is closer to that of control group.
Language英语
WOS IDWOS:000374405100006
PublisherJOURNAL OF CENTRAL SOUTH UNIV TECHNOLOGY
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Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170769
Collection中国科学院大连化学物理研究所
Corresponding AuthorRen Feng-lian
Affiliation1.Cent S Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China
2.China Tobacco Hunan Ind Co Ltd, Technol & Res Ctr, Changsha 410014, Hunan, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Lian Wen-liu,Shi Xian-zhe,Luo Jia,et al. Metabonomic study of rats exposed to cigarette sidestream smoke[J]. JOURNAL OF CENTRAL SOUTH UNIVERSITY,2016,23(3):535-543.
APA Lian Wen-liu,Shi Xian-zhe,Luo Jia,&Ren Feng-lian.(2016).Metabonomic study of rats exposed to cigarette sidestream smoke.JOURNAL OF CENTRAL SOUTH UNIVERSITY,23(3),535-543.
MLA Lian Wen-liu,et al."Metabonomic study of rats exposed to cigarette sidestream smoke".JOURNAL OF CENTRAL SOUTH UNIVERSITY 23.3(2016):535-543.
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