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Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds
Huang, Guang1,2,3; Ou, Junjie1; Wang, Hongwei1,2,3; Ji, Yongsheng1; Wan, Hao1; Zhang, Zhang1,2; Peng, Xiaojun3; Zou, Hanfa1
KeywordBasic Compounds High-performance Liquid Chromatography Michael Addition Stationary Phases Thiol-yne Click Chemistry
Source PublicationJOURNAL OF SEPARATION SCIENCE
2016-04-01
ISSN1615-9306
DOI10.1002/jssc.201501403
Volume39Issue:8Pages:1461-1470
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; W. T. WANG ; DONOR-ACCEPTOR SYSTEMS ; AROMATIC INTERACTIONS ; BETA-CYCLODEXTRIN ; RETENTION ; ALKALOIDS ; PURIFICATION ; BEHAVIOR ; COLUMN
AbstractA novel silica-based stationary phase with branched octadecyl groups was prepared by the sequential employment of the Michael addition reaction and photoinduced thiol-yne click chemistry with 3-aminopropyl-functionalized silicamicrospheres as the initialmaterial. The resulting stationary phase denoted as SiO2-N(C18)(4) was characterized by elemental analysis, FTIR spectroscopy and Raman spectroscopy, demonstrating the existence of branched octadecyl groups in silicamicrospheres. The separations of benzene homologous compounds, acid compounds and amine analogues were conducted, demonstratingmixed-mode separation mechanism on SiO2-N(C18)(4). Baseline separation of basic drugs mixture was acquired with the mobile phase of acetonitrile/H2O (5%, v/v). SiO2-N(C18)(4) was further applied to separate Corydalis yanhusuo Wang water extracts, and more baseline separation peaks were obtained for SiO2-N(C18)(4) than those on Atlantis dC18 column. It can be expected that this new silica-based stationary phase will exhibit great potential in the analysis of basic compounds.
Language英语
WOS IDWOS:000374773000008
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170845
Collection中国科学院大连化学物理研究所
Corresponding AuthorOu, Junjie
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Dalian Univ Technol, State Key Lab Fine Chem, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Huang, Guang,Ou, Junjie,Wang, Hongwei,et al. Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(8):1461-1470.
APA Huang, Guang.,Ou, Junjie.,Wang, Hongwei.,Ji, Yongsheng.,Wan, Hao.,...&Zou, Hanfa.(2016).Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds.JOURNAL OF SEPARATION SCIENCE,39(8),1461-1470.
MLA Huang, Guang,et al."Synthesis of a stationary phase based on silica modified with branched octadecyl groups by Michael addition and photoinduced thiol-yne click chemistry for the separation of basic compounds".JOURNAL OF SEPARATION SCIENCE 39.8(2016):1461-1470.
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