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Rapid "one-pot" preparation of polymeric monolith via photo-initiated thiol-acrylate polymerization for capillary liquid chromatography
Bai, Jingyao1,2; Wang, Hongwei2; Ou, Junjie2; Liu, Zhongshan2; Shen, Yehua1; Zou, Hanfa2
KeywordPolymeric Monolith Photo-initiated Thiol-acrylate Polymerization Capillary Liquid Chromatography
Source PublicationANALYTICA CHIMICA ACTA
2016-06-21
ISSN0003-2670
DOI10.1016/j.aca.2016.04.012
Volume925Pages:88-96
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordENE CLICK CHEMISTRY ; RETENTION-INDEPENDENT PERFORMANCE ; VAN-DEEMTER EQUATION ; SMALL MOLECULES ; ORGANIC MONOLITHS ; STATIONARY-PHASE ; HYBRID MONOLITH ; COLUMNS ; SEPARATION ; ELECTROCHROMATOGRAPHY
AbstractA facile approach was exploited for fast preparation of polymer-based monoliths in UV-transparent fused-silica capillaries via "one-pot" photo-initiated thiol-acrylate polymerization reaction of dipentaerythritolpenta-/hexaacrylate (DPEPA) and 1-octadecanethiol (ODT) in the presence of porogenic solvents (1-butanol and ethylene glycol). Due to relative insensitivity of oxygen inhibition in thiol-ene free-radical polymerization, the polymerization could be performed within 5 min. The effects of composition of prepolymerization solution on the morphology and permeability of poly(ODT-co-DPEPA) monoliths were investigated in detail by adjusting the content of monomer and binary porogen ratio. The physical properties of poly(ODT-co-DPEPA) monoliths were characterized by Fourier transform infrared spectroscopy (FT-IR), mercury intrusion porosimetry (MIP) and nitrogen adsorption/desorption measurement. The evaluation of chromatographic performance was carried out by capillary liquid chromatography (cLC). The results indicated that the poly(ODT-co-DPEPA) monolith was homogeneous and permeable, and also possessed a typical reversed-phase retention mechanism in cLC with high efficiency (similar to 75,000 N m(-1)) for separation of alkylbenzenes. Eventually, the further separation of tryptic digest of proteins by cLC tandem mass spectrometry (cLC-MS/MS) demonstrated its potential in the analysis of biological samples. (C) 2016 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000376130300010
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170925
Collection中国科学院大连化学物理研究所
Corresponding AuthorOu, Junjie; Shen, Yehua; Zou, Hanfa
Affiliation1.NW Univ Xian, Shaanxi Alcohol Ether & Biomass Energy Engn Res C, Key Lab Yulin Desert Plants Resources,Coll Chem &, Key Lab Synthet & Nat Funct Mol Chem,Minist Educ, Xian 710069, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Bai, Jingyao,Wang, Hongwei,Ou, Junjie,et al. Rapid "one-pot" preparation of polymeric monolith via photo-initiated thiol-acrylate polymerization for capillary liquid chromatography[J]. ANALYTICA CHIMICA ACTA,2016,925:88-96.
APA Bai, Jingyao,Wang, Hongwei,Ou, Junjie,Liu, Zhongshan,Shen, Yehua,&Zou, Hanfa.(2016).Rapid "one-pot" preparation of polymeric monolith via photo-initiated thiol-acrylate polymerization for capillary liquid chromatography.ANALYTICA CHIMICA ACTA,925,88-96.
MLA Bai, Jingyao,et al."Rapid "one-pot" preparation of polymeric monolith via photo-initiated thiol-acrylate polymerization for capillary liquid chromatography".ANALYTICA CHIMICA ACTA 925(2016):88-96.
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