DICP OpenIR
Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling
Gao, Peng1,6; Yang, Chunzhang2,7; Nesvick, Cody L.2; Feldman, Michael J.2; Sizdahkhani, Saman2; Liu, Huailei3; Chu, Huiying4; Yang, Fengxu1,2,5; Tang, Ling1; Tian, Jing5; Zhao, Shiguang3; Li, Guohui4; Heiss, John D.2; Liu, Yang1; Zhuang, Zhengping2; Xu, Guowang1
KeywordHypoxia Hypoxia-inducible Factors Hypotaurine Metabolomics Glioma
Source PublicationONCOTARGET
2016-03-22
ISSN1949-2553
Volume7Issue:12Pages:15200-15214
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectOncology ; Cell Biology
WOS Research AreaOncology ; Cell Biology
WOS KeywordMOLECULAR-DYNAMICS SIMULATIONS ; MAGNETIC-RESONANCE-SPECTROSCOPY ; STEM-CELLS ; IN-VITRO ; H-1-NMR SPECTROSCOPY ; METABOLIC PROFILES ; INDUCIBLE FACTORS ; TAURINE LEVELS ; GLIOBLASTOMA ; CANCER
AbstractMetabolomics has shown significant potential in identifying small molecules specific to tumor phenotypes. In this study we analyzed resected tissue metabolites using capillary electrophoresis-mass spectrometry and found that tissue hypotaurine levels strongly and positively correlated with glioma grade. In vitro studies were conducted to show that hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion. In contrast, taurine, the oxidation metabolite of hypotaurine, decreased intracellular hypotaurine and resulted in glioma cell growth arrest. Lastly, a glioblastoma xenograft mice model was supplemented with taurine feed and exhibited impaired tumor growth. Taken together, these findings suggest that hypotaurine is an aberrantly produced oncometabolite, mediating tumor molecular pathophysiology and progression. The hypotaurine metabolic pathway may provide a potentially new target for glioblastoma diagnosis and therapy.
Language英语
WOS IDWOS:000375687200141
PublisherIMPACT JOURNALS LLC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/170963
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhao, Shiguang; Li, Guohui; Zhuang, Zhengping; Xu, Guowang
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
2.NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
3.Harbin Med Univ, Affiliated Hosp 1, Dept Neurosurg, Harbin, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, Dalian, Peoples R China
5.Dalian Polytech Univ, Sch Bioengn, Dalian, Peoples R China
6.Dalian Sixth Peoples Hosp, Clin Lab, Dalian, Peoples R China
7.NCI, Neurooncol Branch, NIH, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Gao, Peng,Yang, Chunzhang,Nesvick, Cody L.,et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling[J]. ONCOTARGET,2016,7(12):15200-15214.
APA Gao, Peng.,Yang, Chunzhang.,Nesvick, Cody L..,Feldman, Michael J..,Sizdahkhani, Saman.,...&Xu, Guowang.(2016).Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling.ONCOTARGET,7(12),15200-15214.
MLA Gao, Peng,et al."Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling".ONCOTARGET 7.12(2016):15200-15214.
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