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Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track
Li, Jiao1; Jia, Zhuqiang2; Kong, Jing1; Zhang, Fuyin3; Fang, Shimeng1; Li, Xiaojie1; Li, Wuwei1; Yang, Xuesong4; Luo, Yong5; Lin, Bingcheng5,6; Liu, Tingjiao1
Source PublicationPLOS ONE
2016-03-08
ISSN1932-6203
DOI10.1371/journal.pone.0150247
Volume11Issue:3
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordCANCER-ASSOCIATED FIBROBLASTS ; TUMOR MICROENVIRONMENT ; BREAST-CANCER ; LUNG-CANCER ; GROWTH ; PROGRESSION ; EXPRESSION ; METASTASIS ; MATRIX ; STROMA
AbstractCarcinoma-associated fibroblasts (CAFs) are critical in determining tumor invasion and metastasis. However the role of CAFs in the invasion of salivary gland adenoid cystic carcinoma (ACC) is poorly understood. In this study, we isolated primary CAFs from two ACC patients. ACC-derived CAFs expressed typical CAF biomarkers and showed increased migration and invasion activity. Conditioned medium collected from CAFs significantly promoted ACC cell migration and invasion. Co-culture of CAFs with ACC cells in a microfluidic device further revealed that CAFs localized at the invasion front and ACC cells followed the track behind the CAFs. Interfering of both matrix metalloproteinase and CXCL12/CXCR4 pathway inhibited ACC invasion promoted by CAFs. Overall, our study demonstrates that ACC-derived CAFs exhibit the most important defining feature of CAFs by promoting cancer invasion. In addition to secretion of soluble factors, CAFs also lead ACC invasion by creating an invasive track in the ECM.
Language英语
WOS IDWOS:000371991300018
PublisherPUBLIC LIBRARY SCIENCE
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/171093
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiu, Tingjiao
Affiliation1.Dalian Med Univ, Coll Stomatol, Dalian, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Oral Surg, Dalian, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dept Oral Surg, Dalian, Peoples R China
4.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian, Peoples R China
5.Dalian Univ Technol, Fac Chem Environm & Biol Sci & Technol, Dalian, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Li, Jiao,Jia, Zhuqiang,Kong, Jing,et al. Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track[J]. PLOS ONE,2016,11(3).
APA Li, Jiao.,Jia, Zhuqiang.,Kong, Jing.,Zhang, Fuyin.,Fang, Shimeng.,...&Liu, Tingjiao.(2016).Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track.PLOS ONE,11(3).
MLA Li, Jiao,et al."Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track".PLOS ONE 11.3(2016).
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