DICP OpenIR
The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes
Li, Dan1; Chen, Qin2; Cao, Jinling3; Chen, Hongxing1; Li, Lixia1; Cedergreen, Nina4; Xie, Haibo5; Xie, Lingtian1
KeywordBisphenol a Lignin-derived Bisphenol (Ld-bp) Japanese Medaka Vitellogenin Histopathology Reproduction
Source PublicationAQUATIC TOXICOLOGY
2016
ISSN0166-445X
DOI10.1016/j.aquatox.2015.11.024
Volume170Pages:199-207
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectMarine & Freshwater Biology ; Toxicology
WOS Research AreaMarine & Freshwater Biology ; Toxicology
WOS KeywordMINNOW PIMEPHALES-PROMELAS ; ADULT FATHEAD MINNOW ; ENDOCRINE DISRUPTION ; SERUM VITELLOGENIN ; DIGESTIVE ENZYMES ; AQUATIC TOXICITY ; SURFACE-WATER ; SALMO-TRUTTA ; BROWN TROUT ; LIFE STAGES
AbstractOne of the ultimate goals of green chemistry is to produce greener and more environmentally friendly chemicals to replace the existing toxic chemicals. In this study, Japanese medaka were exposed to 1.5 mg/L of bisphenol A or lignin-derived bisphenol for 60 days, and the expressions of various biochemical markers, effects on reproduction, and histopathology were evaluated. The results showed that concentrations of liver vitellogenin of LD-BP exposed males were approximately 125% higher compared to the control males. Total number of eggs from the BPA and LD-BP exposed fish was approximately 47% (p < 0.001) and 25% (p < 0.05) less than the control fish, respectively. Total number of brood was lower from the BPA (46%, p <0.05) and LD-BP (17%,p<0.05) exposed fish than that of the control fish. Relative to the control fish, catalase and glutathione-S-transferase were significantly affected by the two chemicals in all tested tissues. BPA and LD-BP caused lipid peroxidation in all the tested tissues. Furthermore, acetylcholinesterase and alpha-glucosidase activity were significantly inhibited. Histopathological analysis showed that both the testis and ovary were mildly damaged by both chemicals. LD-BP affected medaka slightly more severe than BPA except on the reproduction, which was most likely due to different uptake, translocation, binding to targets and metabolism. Our results demonstrated that chronic exposure to both chemicals caused several adverse effects to medaka. Further research on the toxicity of LD-BP to other aquatic organisms is needed before substitution of traditional BPA with LD-BP can be recommended. (C) 2015 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000368564500020
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/171431
Collection中国科学院大连化学物理研究所
Corresponding AuthorXie, Lingtian
Affiliation1.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
3.Shanxi Agr Univ, State Key Lab Ecol Anim Husb & Environm Vet Med, Taigu 030801, Peoples R China
4.Univ Copenhagen, Sect Environm Chem & Phys, Dept Plant & Environm Sci, DK-1871 Copenhagen, Denmark
5.Guizhou Univ, Coll Mat & Met, Dept Polymer Mat & Engn, Beijing 550025, Peoples R China
Recommended Citation
GB/T 7714
Li, Dan,Chen, Qin,Cao, Jinling,et al. The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes[J]. AQUATIC TOXICOLOGY,2016,170:199-207.
APA Li, Dan.,Chen, Qin.,Cao, Jinling.,Chen, Hongxing.,Li, Lixia.,...&Xie, Lingtian.(2016).The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes.AQUATIC TOXICOLOGY,170,199-207.
MLA Li, Dan,et al."The chronic effects of lignin-derived bisphenol and bisphenol A in Japanese medaka Oryzias latipes".AQUATIC TOXICOLOGY 170(2016):199-207.
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