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Tissue amino acid profile could be used to differentiate advanced adenoma from colorectal cancer
Gao, Peng1,2,3,4; Zhou, Changjiang5; Zhao, Liang1; Zhang, Guihua6; Zhang, Yong1
KeywordColorectal Cancer Adenoma Metabolomics Amino Acids
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2016-01-25
ISSN0731-7085
DOI10.1016/j.jpba.2015.11.007
Volume118Pages:349-355
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordMASS-SPECTROMETRY ; COLON-CANCER ; METABOLOMICS ; METABOLISM
AbstractAdvanced adenomas are of higher risk to progress to colorectal cancer (CRC), the third leading cause of cancerous death worldwide. Endoscopy-based adenoma removal greatly contributes to arresting the progression of adenoma to CRC. Precise diagnosis, post-polypectomy surveillance and the follow-up clinical decisions predominantly depend on histopathologic inspection of the resected tissues. The common artificial histological inspection is not fully reliable and is only compatible with the en bloc removed tissues. An alternative measure ensuring more objective tissue malignance appraisal, which is applicable to various endoscopically acquired sample types are highly appreciated. In this study, we firstly employed capillary electrophoresis mass spectrometry-based untargeted metabolomic technique to analyze CRC and corresponding paracancerous tissues to narrow the scope of malignancy-related metabolite changes. The primary results implied the most perturbated metabolites by CRC onset were amino acids. Subsequently, a targeted amino acid analysis by ultra-performance liquid chromatography mass spectrometry indicated 9 amino acids were of different content between advanced adenoma and CRC tissues. Finally, regression analysis of the 9 differential amino acids exhibited that methionine, tyrosine, valine and isoleucine could be used to differentiate CRC from advanced adenomas with good sensitivity and specificity (p <0.001). Area under the receiver operating characteristic curve was 0.991. This study demonstrated the utility of metabolomic analysis in assisting malignance evaluation of colorectal neoplasia and the potential value of amino acids analysis in clinical pathology practice. (C) 2015 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000367633800041
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/171445
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Yong
Affiliation1.Dalian Sixth Peoples Hosp, Dalian 116031, Peoples R China
2.Liaoning Med Univ, Affiliated Hosp 1, Personalized Treatment & Diag Res Ctr, Jinzhou 121001, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Jinzhou 121001, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
5.Dalian Univ, Xinhua Affiliated Hosp, Anorectal Dept, Dalian 116033, Peoples R China
6.Dalian Univ, Xinhua Affiliated Hosp, Dept Gastroenterol, Dalian 116033, Peoples R China
Recommended Citation
GB/T 7714
Gao, Peng,Zhou, Changjiang,Zhao, Liang,et al. Tissue amino acid profile could be used to differentiate advanced adenoma from colorectal cancer[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2016,118:349-355.
APA Gao, Peng,Zhou, Changjiang,Zhao, Liang,Zhang, Guihua,&Zhang, Yong.(2016).Tissue amino acid profile could be used to differentiate advanced adenoma from colorectal cancer.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,118,349-355.
MLA Gao, Peng,et al."Tissue amino acid profile could be used to differentiate advanced adenoma from colorectal cancer".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 118(2016):349-355.
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