DICP OpenIR
ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs
Fan, Jing1; Wang, Ke1,2; Du, Xian; Wang, Jianshu1; Chen, Suli1; Wang, Yimin1; Shi, Min1; Zhang, Li1; Wu, Xudong3; Zheng, Dinghai4; Wang, Changshou1; Wang, Lantian1; Tian, Bin4; Li, Guohui3; Zhou, Yu2; Cheng, Hong1
Corresponding AuthorCheng, Hong(hcheng@sibcb.ac.cn)
Keyword3-end processing ALYREF mRNA export RD-histone mRNA SLBP
Source PublicationEMBO JOURNAL
2019-05-02
ISSN0261-4189
DOI10.15252/embj.201899910
Volume38Issue:9Pages:16
Funding ProjectNational Key R&D Program of China[2017YFA0504400] ; National Natural Science Foundation of China[31570822] ; National Natural Science Foundation of China[31770880] ; National Natural Science Foundation of China[31800686] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000] ; China Postdoctoral Science Foundation[2018M630481] ; China Postdoctoral Science Foundation[BX20180333]
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS KeywordLOOP BINDING-PROTEIN ; HUMAN TREX COMPLEX ; 3' END ; U7 SNRNP ; FACTOR YRA1 ; STEM ; 3'-END ; LSM11 ; INTERACTS ; FLASH
AbstractThe RNA-binding protein ALYREF plays key roles in nuclear export and also 3-end processing of polyadenylated mRNAs, but whether such regulation also extends to non-polyadenylated RNAs is unknown. Replication-dependent (RD)-histone mRNAs are not polyadenylated, but instead end in a stem-loop (SL) structure. Here, we demonstrate that ALYREF prevalently binds a region next to the SL on RD-histone mRNAs. SL-binding protein (SLBP) directly interacts with ALYREF and promotes its recruitment. ALYREF promotes histone pre-mRNA 3-end processing by facilitating U7-snRNP recruitment through physical interaction with the U7-snRNP-specific component Lsm11. Furthermore, ALYREF, together with other components of the TREX complex, enhances histone mRNA export. Moreover, we show that 3-end processing promotes ALYREF recruitment and histone mRNA export. Together, our results point to an important role of ALYREF in coordinating 3-end processing and nuclear export of non-polyadenylated mRNAs.
Language英语
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
WOS IDWOS:000468399700010
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/171848
Collection中国科学院大连化学物理研究所
Corresponding AuthorCheng, Hong
Affiliation1.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,CAS, Shanghai Key Lab Mol Androl,State Key Lab Mol Bio, Shanghai, Peoples R China
2.Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan, Hubei, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, Dalian, Peoples R China
4.Rutgers New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ USA
Recommended Citation
GB/T 7714
Fan, Jing,Wang, Ke,Du, Xian,et al. ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs[J]. EMBO JOURNAL,2019,38(9):16.
APA Fan, Jing.,Wang, Ke.,Du, Xian.,Wang, Jianshu.,Chen, Suli.,...&Cheng, Hong.(2019).ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs.EMBO JOURNAL,38(9),16.
MLA Fan, Jing,et al."ALYREF links 3-end processing to nuclear export of non-polyadenylated mRNAs".EMBO JOURNAL 38.9(2019):16.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Fan, Jing]'s Articles
[Wang, Ke]'s Articles
[Du, Xian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Fan, Jing]'s Articles
[Wang, Ke]'s Articles
[Du, Xian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Fan, Jing]'s Articles
[Wang, Ke]'s Articles
[Du, Xian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.