DICP OpenIR
Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling
Zhou, Ye1,2; Liu, Zheyi1; Zhang, Jinbao3; Dou, Tongyi1; Chen, Jin1; Ge, Guangbo1,4; Zhu, Shujia3; Wang, Fangjun1
Corresponding AuthorZhu, Shujia(shujiazhu@ion.ac.cn) ; Wang, Fangjun(wangfj@dicp.ac.cn)
Source PublicationCHEMICAL COMMUNICATIONS
2019-04-18
ISSN1359-7345
DOI10.1039/c9cc00520j
Volume55Issue:30Pages:4311-4314
Funding ProjectNational Key R&D Program of China[2016YFF0200504] ; National Natural Science Foundation of China[91853101] ; National Natural Science Foundation of China[21675152] ; DICP[ZZBS201603] ; Shanghai Rising-Star Program[17QA1404800]
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordNMDA RECEPTOR ; ALLOSTERIC MODULATORS ; MOLECULAR-MECHANISMS ; MASS-SPECTROMETRY ; METHYLATION ; IDENTIFICATION ; SUBUNIT ; GLYCINE ; ENZYMES ; BINDING
AbstractHerein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-Omethyltransferase and the N-methyl-D-aspartate receptors have been predicted, including both binding regions and related conformational changes.
Language英语
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program
WOS IDWOS:000467979900037
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/171908
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhu, Shujia; Wang, Fangjun
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Ye,Liu, Zheyi,Zhang, Jinbao,et al. Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling[J]. CHEMICAL COMMUNICATIONS,2019,55(30):4311-4314.
APA Zhou, Ye.,Liu, Zheyi.,Zhang, Jinbao.,Dou, Tongyi.,Chen, Jin.,...&Wang, Fangjun.(2019).Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling.CHEMICAL COMMUNICATIONS,55(30),4311-4314.
MLA Zhou, Ye,et al."Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling".CHEMICAL COMMUNICATIONS 55.30(2019):4311-4314.
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