DICP OpenIR
Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway
Han, Yang1; Zhang, Lin1; Yu, Xiao2; Wang, Shidan1; Xu, Chunyan1; Yin, Heng3; Wang, Shujing1
Corresponding AuthorYin, Heng(yinheng@dicp.ac.cn) ; Wang, Shujing(wangshujing@dlmedu.edu.cn)
Source PublicationCELL DEATH & DISEASE
2019-05-10
ISSN2041-4889
DOI10.1038/s41419-019-1560-y
Volume10Pages:14
Funding ProjectNational Natural Science Foundation of China[31470799] ; Natural Science Foundation of Liaoning Province[20170540288] ; Special Fund of Dalian city for Distinguished Young Scholars[2017RJ07] ; National Key R&D Program of China[2017YF0200900] ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences
WOS SubjectCell Biology
WOS Research AreaCell Biology
WOS KeywordBETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE ; C-JUN ; ENDOPLASMIC-RETICULUM ; COLON-CANCER ; SIALYLATION ; EXPRESSION ; INVASION ; ADHESION ; GLYCANS ; DEATH
AbstractChitosan oligosaccharides have been reported to inhibit various tumors. However, the water-soluble marine plant oligosaccharide alginate oligosaccharide (AOS) has only rarely been reported to have anti-cancer effects. Moreover, the inhibitory effect of AOS on prostate cancer and the underlying molecular mechanism remain unknown. This study shows that AOS inhibited cell growth, which was consistent with the attenuation of alpha 2,6-sialylation modification. Furthermore, AOS inhibited ST6Gal-1 promoter activity and thus affected transcriptional processes. In addition, AOS could activate the Hippo/YAP pathway and block the recruitment of both the coactivator YAP and c-Jun. Furthermore, YAP interacted with the transcription factor c-Jun and regulated the transcriptional activity of the downstream target ST6Gal-1 gene. Consistent with in vitro data, AOS suppressed the tumorigenicity of prostate cancer cells via the Hippo/YAP pathway in vivo. In summary, these data indicate that AOS slows the proliferation of prostate cancer and provides a basis for the healthy function of kelp in traditional cognition.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences
WOS IDWOS:000468671400001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/171934
Collection中国科学院大连化学物理研究所
Corresponding AuthorYin, Heng; Wang, Shujing
Affiliation1.Dalian Med Univ, Coll Basic Med Sci, Inst Glycobiol, Dept Biochem & Mol Biol, Dalian, Liaoning, Peoples R China
2.Dalian Med Univ, Coll Basic Med Sci, Dept Pathol, Dalian, Liaoning, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Han, Yang,Zhang, Lin,Yu, Xiao,et al. Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway[J]. CELL DEATH & DISEASE,2019,10:14.
APA Han, Yang.,Zhang, Lin.,Yu, Xiao.,Wang, Shidan.,Xu, Chunyan.,...&Wang, Shujing.(2019).Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.CELL DEATH & DISEASE,10,14.
MLA Han, Yang,et al."Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway".CELL DEATH & DISEASE 10(2019):14.
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