DICP OpenIR
Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages
Ye, Guozhu1,2; Chen, Guoyou3; Gao, Han2,4; Lin, Yi2; Liao, Xu2; Zhang, Han2; Liu, Xinyu5; Chi, Yulang2; Huang, Qiansheng2; Zhu, Huimin2; Fan, Yuhua3; Dong, Sijun1,2
Corresponding AuthorFan, Yuhua(fyh198306@126.com) ; Dong, Sijun(sjdong@iue.ac.cn)
Keywordatherosclerosis cholesterol fatty acid intestinal macrophage peroxisome proliferator-activated receptor resveratrol
Source PublicationJOURNAL OF CELLULAR AND MOLECULAR MEDICINE
2019-06-01
DOI10.1111/jcmm.14323
Volume23Issue:6Pages:4313-4325
Funding ProjectNational Natural Science Foundation of China[21507128] ; National Natural Science Foundation of China[41390240] ; National Natural Science Foundation of China[21777158] ; National Natural Science Foundation of China[21477124] ; National Natural Science Foundation of China[21677140] ; Natural Science Foundation of Fujian Province, China[2018J01020] ; Science and Technology Program of Fujian Province[2016T3005] ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences[J008] ; Postdoctoral Foundation of Heilongjiang Province[LBH-Z15160]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province
WOS SubjectCell Biology ; Medicine, Research & Experimental
WOS Research AreaCell Biology ; Research & Experimental Medicine
WOS KeywordNUCLEAR RECEPTORS ; L-ARGININE ; OXIDATIVE STRESS ; GUT MICROBIOTA ; FATTY-ACIDS ; METABOLISM ; CHOLESTEROL ; METABOLOMICS ; ABSORPTION ; TRANSPORTERS
AbstractDisordered intestinal metabolism is highly correlated with atherosclerotic diseases. Resveratrol protects against atherosclerotic diseases. Accordingly, this study aims to discover novel intestinal proatherosclerotic metabolites and potential therapeutic targets related to the anti-atherosclerotic effects of resveratrol. An untargeted metabolomics approach was employed to discover novel intestinal metabolic disturbances during atherosclerosis and resveratrol intervention. We found that multiple intestinal metabolic pathways were significantly disturbed during atherosclerosis and responsive to resveratrol intervention. Notably, resveratrol abolished intestinal fatty acid and monoglyceride accumulation in atherosclerotic mice. Meanwhile, oleate accumulation was one of the most prominent alterations in intestinal metabolism. Moreover, resveratrol attenuated oleate-triggered accumulation of total cholesterol, esterified cholesterol and neutral lipids in mouse RAW 264.7 macrophages by activating ABC transporter A1/G1-mediated cholesterol efflux through PPAR (peroxisome proliferator-activated receptor) alpha/gamma activation. Furthermore, we confirmed that PPAR alpha and PPAR gamma activation by WY14643 and pioglitazone, respectively, alleviated oleate-induced accumulation of total cholesterol, esterified cholesterol and neutral lipids by accelerating ABC transporter A1/G1-mediated cholesterol efflux. This study provides the first evidence that resveratrol abolishes intestinal fatty acid and monoglyceride accumulation in atherosclerotic mice, and that resveratrol suppresses oleate-induced accumulation of total cholesterol, esterified cholesterol and neutral lipids in macrophages by activating PPAR alpha/gamma signalling.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Fujian Province, China ; Natural Science Foundation of Fujian Province, China ; Science and Technology Program of Fujian Province ; Science and Technology Program of Fujian Province ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences ; Postdoctoral Foundation of Heilongjiang Province ; Postdoctoral Foundation of Heilongjiang Province
WOS IDWOS:000470659500047
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172032
Collection中国科学院大连化学物理研究所
Corresponding AuthorFan, Yuhua; Dong, Sijun
Affiliation1.Chinese Acad Sci, Inst Urban Environm, Ctr Excellence Reg Atmospher Environm, Xiamen, Fujian, Peoples R China
2.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen, Fujian, Peoples R China
3.Harbin Med Univ Daqing, Coll Pharm, Daqing, Heilongjiang, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Ye, Guozhu,Chen, Guoyou,Gao, Han,et al. Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2019,23(6):4313-4325.
APA Ye, Guozhu.,Chen, Guoyou.,Gao, Han.,Lin, Yi.,Liao, Xu.,...&Dong, Sijun.(2019).Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,23(6),4313-4325.
MLA Ye, Guozhu,et al."Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 23.6(2019):4313-4325.
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