DICP OpenIR
Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues
Wang, Lei1; Liu, Bin1; Liu, Yuxue2; Sun, Yue1; Liu, Wujun3; Yu, Dayu1; Zhao, Zongbao K.2
Corresponding AuthorYu, Dayu(yudy@neepu.edu.cn) ; Zhao, Zongbao K.(zhaozb@dicp.ac.cn)
Source PublicationORGANIC LETTERS
2019-05-03
ISSN1523-7060
DOI10.1021/acs.orglett.9b00935
Volume21Issue:9Pages:3218-3222
Funding ProjectNational Natural Science Foundation of China[21708003] ; National Natural Science Foundation of China[31470787] ; National Natural Science Foundation of China[21837002] ; Science and Technology Research Project of Jilin Province, China[20170519015JH]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordNAD(+) TRANSPORTER ; COFACTORS ; IDENTIFICATION ; IMPORT
AbstractAn Escherichia coli strain was constructed for the efficient import of nicotinamide adenine dinucleotide (NAD) analogues into cells by limiting extracellular degradation while expressing an efficient NAD importer. In vivo functions of three NAD analogues were characterized. Nicotinamide hypoxanthine dinucleotide was identified as an inhibitor of NAD synthesis. Nicotinamide cytosine dinucleotide had excellent biocompatibility and was used for characterizing a growth-dependent degradation of in vivo nicotinamide cofactors.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Research Project of Jilin Province, China ; Science and Technology Research Project of Jilin Province, China
WOS IDWOS:000467320000052
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172061
Collection中国科学院大连化学物理研究所
Corresponding AuthorYu, Dayu; Zhao, Zongbao K.
Affiliation1.Northeast Elect Power Univ, Sch Chem Engn, Jilin 132012, Peoples R China
2.Chinese Acad Sci, Div Biotechnol, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Dalian Med Univ, Inst Canc Stem Cell, Dalian 116044, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lei,Liu, Bin,Liu, Yuxue,et al. Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues[J]. ORGANIC LETTERS,2019,21(9):3218-3222.
APA Wang, Lei.,Liu, Bin.,Liu, Yuxue.,Sun, Yue.,Liu, Wujun.,...&Zhao, Zongbao K..(2019).Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues.ORGANIC LETTERS,21(9),3218-3222.
MLA Wang, Lei,et al."Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues".ORGANIC LETTERS 21.9(2019):3218-3222.
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