DICP OpenIR
Characteristics of bile acids metabolism profile in the second and third trimesters of normal pregnancy
Zhu, Bo1,2; Yin, Peiyuan3,4; Ma, Zhixin1,2; Ma, Yu1,2; Zhang, Hong1,2; Kong, Hongwei3; Zhu, Yuning1,2
Corresponding AuthorZhu, Yuning(zyn@zju.edu.cn)
KeywordBile acids Metabolism profile Trimester
Source PublicationMETABOLISM-CLINICAL AND EXPERIMENTAL
2019-06-01
ISSN0026-0495
DOI10.1016/j.metabol.2019.04.004
Volume95Pages:77-83
Funding ProjectNational Key R&D Program of China[2018YFC1002700] ; National Key R&D Program of China[2018YFC1002702]
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
WOS SubjectEndocrinology & Metabolism
WOS Research AreaEndocrinology & Metabolism
WOS KeywordINTRAHEPATIC CHOLESTASIS ; RECEPTOR ; PROGESTERONE ; PLACENTA
AbstractPurpose: Bile adds are a group of cholesterol metabolites functioning as key regulators of glucose, lipid, and energy metabolism. Their homeostatic control is essential to the physiology of the normal pregnancy. Abnormalities of bile acids regulation in pregnancy lead to intrahepatic cholestasis of pregnancy, a serious condition associated with a number of fetal and maternal morbidities. Dysregulation of glucose and lipids is also tied to perturbations in bile add concentrations. Changes in bile add metabolic profiles in the second and third trimesters of pregnancy have been incompletely explored. We seek to establish pregnancy-specific normative ranges for a number of bile acids in women in the second and third trimesters and explore changes in their concentrations in the period from 12 to 40 weeks gestation. Procedure: In this cross-sectional study, a total of 782 normal pregnant women were enrolled including n = 290 in the second trimester (12-28 weeks) and n = 492 in the third trimester (29-40 weeks). The concentrations of 14 bile acids were measured by liquid chromatography and mass spectrometry (LC-MS) and compared at various time points. Reference intervals of these bile acids were calculated using standard statistical techniques. Results: A reference interval profile of 14 bile acids from a cohort of 782 normal pregnant women was developed. Significant differences in concentration were found between the second trimester and the third trimester. Unconjugated bile acids dominate the bile acid profile in the second trimester, while conjugated bile acids, especially (taurine-conjugated ) dominate in the third trimester. 28-31 weeks gestation was the notable change period of bile acid metabolism. Conclusion: This study establishes pregnancy-specific reference intervals for bile acids in the second and third trimesters. As bile acid composition changes with gestational age, this study establishes a foundation for trimester-specific clinical interpretation of bile acid metabolic profiles in pregnant women. (C) 2019 Elsevier Inc. All rights reserved.
Language英语
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
WOS IDWOS:000470307800009
PublisherW B SAUNDERS CO-ELSEVIER INC
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172134
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhu, Yuning
Affiliation1.Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Univ, Clin Prenatal Diag Ctr, Womens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Bo,Yin, Peiyuan,Ma, Zhixin,et al. Characteristics of bile acids metabolism profile in the second and third trimesters of normal pregnancy[J]. METABOLISM-CLINICAL AND EXPERIMENTAL,2019,95:77-83.
APA Zhu, Bo.,Yin, Peiyuan.,Ma, Zhixin.,Ma, Yu.,Zhang, Hong.,...&Zhu, Yuning.(2019).Characteristics of bile acids metabolism profile in the second and third trimesters of normal pregnancy.METABOLISM-CLINICAL AND EXPERIMENTAL,95,77-83.
MLA Zhu, Bo,et al."Characteristics of bile acids metabolism profile in the second and third trimesters of normal pregnancy".METABOLISM-CLINICAL AND EXPERIMENTAL 95(2019):77-83.
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