DICP OpenIR
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress
Zong, Yue1; Zhang, Chen-Song1; Li, Mengqi1; Wang, Wen2,3; Wang, Zhichao2,3; Hawley, Simon A.4; Ma, Teng1; Feng, Jin-Wei1; Tian, Xiao1; Qi, Qu1; Wu, Yu-Qing1; Zhang, Cixiong1; Ye, Zhiyun1; Lin, Shu-Yong1; Piao, Hai-Long2,3; Hardie, D. Grahame4; Lin, Sheng-Cai1
Corresponding AuthorLin, Sheng-Cai(linsc@xmu.edu.cn)
Source PublicationCELL RESEARCH
2019-06-01
ISSN1001-0602
DOI10.1038/s41422-019-0163-6
Volume29Issue:6Pages:460-473
Funding ProjectNational Key R&D Program of China[2016YFA0502001] ; National Natural Science Foundation of China[31730058] ; National Natural Science Foundation of China[31430094] ; National Natural Science Foundation of China[31601152] ; National Natural Science Foundation of China[31690101] ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University[SKLCSB2017KF002] ; Wellcome Trust[204766/Z/16/Z]
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust
WOS SubjectCell Biology
WOS Research AreaCell Biology
WOS KeywordACETYL-COA CARBOXYLASE ; PROTEIN-KINASE ; SUBCELLULAR-LOCALIZATION ; DIFFERENTIAL REGULATION ; MITOCHONDRIAL FISSION ; HEPATIC STEATOSIS ; INDUCED AUTOPHAGY ; STRUCTURAL BASIS ; RAG GTPASES ; PHOSPHORYLATION
AbstractAMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity.
Language英语
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University ; Wellcome Trust ; Wellcome Trust
WOS IDWOS:000470082200007
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172144
Collection中国科学院大连化学物理研究所
Corresponding AuthorLin, Sheng-Cai
Affiliation1.Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Fujian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Univ Dundee, Coll Life Sci, Div Cell Signalling & Immunol, Dundee DD1 5EH, Scotland
Recommended Citation
GB/T 7714
Zong, Yue,Zhang, Chen-Song,Li, Mengqi,et al. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress[J]. CELL RESEARCH,2019,29(6):460-473.
APA Zong, Yue.,Zhang, Chen-Song.,Li, Mengqi.,Wang, Wen.,Wang, Zhichao.,...&Lin, Sheng-Cai.(2019).Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.CELL RESEARCH,29(6),460-473.
MLA Zong, Yue,et al."Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress".CELL RESEARCH 29.6(2019):460-473.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zong, Yue]'s Articles
[Zhang, Chen-Song]'s Articles
[Li, Mengqi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zong, Yue]'s Articles
[Zhang, Chen-Song]'s Articles
[Li, Mengqi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zong, Yue]'s Articles
[Zhang, Chen-Song]'s Articles
[Li, Mengqi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.