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Spectroscopic approach for the interaction of carbon nanoparticles with cytochrome c and BY-2 cells: Protein structure and mitochondrial function
Chen, Lijuan1,2,3; Hao, Jufang4; Xu, Liangtao5; Meng, Xiangyu5; Li, Xiang5; Nie, Cong5; Xie, Fuwei5; Liu, Kejian5; Peng, Xiaojun1; Xie, Jianping5; Liang, Taibo5; Guo, Zhijiang6
Corresponding AuthorXie, Jianping(ztridicp@126.com)
KeywordCarbon nanopartides Cytochrome c Conformation Redox potential Mitochondrial function
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2019-10-01
ISSN0141-8130
DOI10.1016/j.ijbiomac.2019.07.076
Volume138Pages:29-36
Funding ProjectCollege of Chemistry and Molecular Engineering, Zhengzhou University
Funding OrganizationCollege of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS KeywordSILICA NANOPARTICLES ; INDUCED APOPTOSIS ; GRAPHENE OXIDE ; NANOTUBES ; ACTIVATION ; STABILITY ; KINETICS
AbstractIn this study, we employed multiple spectroscopic methods to analyze the effects of carbon nanoparticles (CNPs) on structure of cytochrome c (Cyt c) and mitochondrial function in plant cells. The tertiary structures of aromatic amino acid in Cyt c were not changed after addition of CNPs. Cyt c was found to be absorbed on the surfaces of CNPs in a non-linear manner and only bound Cyt c can be reduced. In addition, the binding of Cyt c was found to increase the diameter of CNPs at lower concentrations. The redox potential of Cyt c was almost not affected after treatment with CNPs. There were no obvious differences in cellular ATP after exposure to CNPs, and the mitochondrial membrane potential (MMP) was significantly decreased once the CNPs concentration exceeded 31.25 mu g/mL. The levels of reactive oxygen species (ROS) also were increased in BY-2 cells. Taken together, these findings provide basis for the interactions between CNPs and Cyt c, as well as the effect of CNPs treatment on the mitochondria function in plant cells. (C) 2019 Published by Elsevier B.V.
Language英语
Funding OrganizationCollege of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University ; College of Chemistry and Molecular Engineering, Zhengzhou University
WOS IDWOS:000487569000004
PublisherELSEVIER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172561
Collection中国科学院大连化学物理研究所
Corresponding AuthorXie, Jianping
Affiliation1.Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
4.Staff Dev Inst China Natl Tobacco Corp, 7 Xinyuan Rd, Zhengzhou 450008, Henan, Peoples R China
5.Zhengzhou Tobacco Res Inst CNTC, 2 Fengyang Rd, Zhengzhou 450001, Henan, Peoples R China
6.Beijing Xinna Int Hitech Mat Co Ltd, 14 Kechuang St, Beijing 100076, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lijuan,Hao, Jufang,Xu, Liangtao,et al. Spectroscopic approach for the interaction of carbon nanoparticles with cytochrome c and BY-2 cells: Protein structure and mitochondrial function[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,138:29-36.
APA Chen, Lijuan.,Hao, Jufang.,Xu, Liangtao.,Meng, Xiangyu.,Li, Xiang.,...&Guo, Zhijiang.(2019).Spectroscopic approach for the interaction of carbon nanoparticles with cytochrome c and BY-2 cells: Protein structure and mitochondrial function.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,138,29-36.
MLA Chen, Lijuan,et al."Spectroscopic approach for the interaction of carbon nanoparticles with cytochrome c and BY-2 cells: Protein structure and mitochondrial function".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 138(2019):29-36.
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