DICP OpenIR
pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy
Qin, Ya-Ting1; Peng, Hui1; He, Xi-Wen1; Li, Wen-You1,2; Zhang, Yu-Kui1,3
Corresponding AuthorLi, Wen-You(wyli@mail.nankai.edu.cn)
KeywordZIF-8 Si-Gd nanoparticles chemo-/photodynamic imaging drug delivery
Source PublicationACS APPLIED MATERIALS & INTERFACES
2019-09-18
ISSN1944-8244
DOI10.1021/acsami.9b12641
Volume11Issue:37Pages:34268-34281
Funding ProjectNational Natural Science Foundation of China[21775077] ; National Natural Science Foundation of China[21475069] ; Tianjin Natural Science Foundation[16JCZDJC37200]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS KeywordMETAL-ORGANIC FRAMEWORKS ; ONE-POT SYNTHESIS ; SILICON NANOPARTICLES ; PHOTODYNAMIC THERAPY ; ROOM-TEMPERATURE ; ANTICANCER DRUG ; GRAPHENE OXIDE ; DELIVERY ; DOXORUBICIN ; CARRIER
AbstractA multifunctional diagnosis and treatment integration platform is crucial in cancer treatments. Here, we show that by integrating Gd-doped silicon nanoparticles (Si-Gd NPs), chlorine e6 (Ce6), doxorubicin (DOX), zeolitic imidazolate framework-8 (ZIF-8), poly(2-(diethylamino)ethyl methacrylate) polymers (HOOC-PDMAEMA-SH), and folic acid-polyethylene glycol)-maleimide (MaL-PEG-FA) into one single nanoplatform by a self-assembly method, novel multifunctional MOFs (named FZIF-8/DOX-PD-FA) are synthesized with great biocompatibility and tumor targeting as well as pH responsiveness and no drug leakage for drug delivery. In the design, Si-Gd NPs and Ce6 embedded in the nanocomposites are used for magnetic resonance and fluorescence dual-modal imaging, respectively. DOX loaded by the FZIF-8/DOX-PD-FA porous structure is used for chemotherapy, while Ce6 is excited by near-infrared radiation (NIR) for photodynamic therapy. In addition, the pH-responsive ability of HOOC-PDMAEMA-SH to effectively prevent drug leakage is demonstrated by drug release studies in vitro. From the results of confocal microscopy imaging in vitro and fluorescence/magnetic resonance imaging in vivo, FZIF-8/DOX-PD-FA showed a targeting effect on MCF-7 cancer cells. More importantly, the results of treatment experiments on tumor-bearing mice showed that the tumor volume of the FZIF-8/DOX-PD-FA + NIR group is decreased the most compared to the original volume. Owing to the unique dual-modal imaging capability and excellent chemo-/photodynamic combinational cancer therapy effect, the present hybrid nanocarrier provides a new research platform for a new generation of theranostic nanoparticles.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation
WOS IDWOS:000487179900081
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172637
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi, Wen-You
Affiliation1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China
2.Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Qin, Ya-Ting,Peng, Hui,He, Xi-Wen,et al. pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(37):34268-34281.
APA Qin, Ya-Ting,Peng, Hui,He, Xi-Wen,Li, Wen-You,&Zhang, Yu-Kui.(2019).pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy.ACS APPLIED MATERIALS & INTERFACES,11(37),34268-34281.
MLA Qin, Ya-Ting,et al."pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy".ACS APPLIED MATERIALS & INTERFACES 11.37(2019):34268-34281.
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