DICP OpenIR
Reductive methylation labeling, from quantitative to structural proteomics
Liu, Zheyi1; Zhou, Ye1; Liu, Jing2; Chen, Jin1; Heck, Albert J. R.3; Wang, Fangjun1
Corresponding AuthorWang, Fangjun(wangfj@dicp.ac.cn)
KeywordReductive methylation Stable isotope dimethyl labeling Mass spectrometry Quantitative proteomics N-termini profiling Structural proteomics Lysine reactivity profiling
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
2019-09-01
ISSN0165-9936
DOI10.1016/j.trac.2019.07.009
Volume118Pages:771-778
Funding ProjectNational Key R&D Program of China[2016YFF0200504] ; National Natural Science Foundation of China[91853101] ; National Natural Science Foundation of China[21675152] ; National Natural Science Foundation of China[81702995] ; DICP[ZZBS201603]
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordPROTEIN N-TERMINI ; FORMALDEHYDE-INDUCED MODIFICATIONS ; CHEMICAL CROSS-LINKING ; MASS-SPECTROMETRY ; PHOSPHOPROTEOME ANALYSIS ; AMINO-ACID ; IDENTIFICATION ; LYSINE ; ENRICHMENT ; THROUGHPUT
AbstractReductive methylation is a highly reactive and selective chemical labeling method and plays an important role in proteomic analysis. Various applications of reductive methylation have been developed and have substantially promoted the scope of proteomic analysis to date. Aside from a well-known method for introducing isotopes, this reaction could also be conducted under biological conditions and has little structural perturbations. In this paper, we reviewed the recent developments and applications of reductive methylation in quantitative proteomics and protein N-terminal profiling, along with the emerging applications in structural proteomics for monitoring protein structural/conformational changes under various conditions. (C) 2019 Elsevier B.V. All rights reserved.
Language英语
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP
WOS IDWOS:000486383900060
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172828
Collection中国科学院大连化学物理研究所
Corresponding AuthorWang, Fangjun
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China
3.Univ Utrecht, Utrecht Inst Pharmaceut Sci, Bijvoet Ctr Biomol Res, Biomol Mass Spectrometry & Prote, Padualaan 8, NL-3584 CH Utrecht, Netherlands
Recommended Citation
GB/T 7714
Liu, Zheyi,Zhou, Ye,Liu, Jing,et al. Reductive methylation labeling, from quantitative to structural proteomics[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,118:771-778.
APA Liu, Zheyi,Zhou, Ye,Liu, Jing,Chen, Jin,Heck, Albert J. R.,&Wang, Fangjun.(2019).Reductive methylation labeling, from quantitative to structural proteomics.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,118,771-778.
MLA Liu, Zheyi,et al."Reductive methylation labeling, from quantitative to structural proteomics".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 118(2019):771-778.
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