DICP OpenIR
Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury
Ma, Zhenhua1,2; Wang, Xiaomei1; Yin, Peiyuan; Wu, Ruihong1,3; Zhou, Lina3; Xu, Guowang3; Niu, Junqi1
Corresponding AuthorXu, Guowang(xugw@dicp.ac.cn) ; Niu, Junqi(junqi_niu@163.com)
Keywordbile acid biomarkers drug induced liver injury serum metabolic profiling UHPLC-MS/MS
Source PublicationMEDICINE
2019-08-01
ISSN0025-7974
DOI10.1097/MD.0000000000016717
Volume98Issue:31Pages:11
Funding ProjectNational Basic Research Program of China (973 Program)[2015CB554304] ; National Natural Science Foundation of China[81373057] ; Health and Family Planning Commission Project of Jilin Province[2016Q043]
Funding OrganizationNational Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province
WOS SubjectMedicine, General & Internal
WOS Research AreaGeneral & Internal Medicine
WOS KeywordHEPATOCELLULAR-CARCINOMA ; CAUSALITY ASSESSMENT ; MASS-SPECTROMETRY ; ADVERSE REACTIONS ; HEPATITIS-B ; MODEL ; METABONOMICS ; INFLAMMATION ; HEPATOCYTES ; VALIDATION
AbstractThis study aims to determine the non-invasive, reliable and sensitive biochemical parameters for the diagnosis of drug-induced liver injury (DILI). Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and selected reaction monitoring (SRM) were used to profile the serum metabolome and quantify 15 targeted bile acid metabolites, respectively, in samples obtained from 38 DILI patients and 30 healthy controls. A comparison of the resulting serum metabolome profiles of the study participants revealed significant differences between DILI patients and healthy controls. Specifically, serum palmitic acid, taurochenodeoxycholic acid, glycocholic acid (GCA), and tauroursodeoxycholic acid (TUDCA) levels were significantly higher, and serum lysophosphatidylethanolamine levels were significantly lower in DILI patients vs healthy controls (P<.001). Furthermore, the SRM assay of bile acids revealed that the increase in GCA, taurocholic acid (TCA), TUDCA, glycochenodeoxycholic acid (GCDCA), glycochenodeoxycholic sulfate (GCDCS), and taurodeoxycholic acid (TDCA) corresponded to a higher degree of liver damage. These results also indicate that serum concentrations of chenodeoxycholic acid (CDCA), deoxycholic acid (DCA) and lithocholic acid (LCA) were significantly lower in patients with severe DILI, when compared to healthy controls, and that this decrease was closely correlated to the severity of liver damage. Taken together, these results demonstrate that bile acids could serve as potential biomarkers for the early diagnosis and severity of DILI.
Language英语
Funding OrganizationNational Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Health and Family Planning Commission Project of Jilin Province ; Health and Family Planning Commission Project of Jilin Province
WOS IDWOS:000483216200065
PublisherLIPPINCOTT WILLIAMS & WILKINS
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/172954
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu, Guowang; Niu, Junqi
Affiliation1.Jilin Univ, Hosp 1, Dept Hepatol, Changchun, Jilin, Peoples R China
2.Beihua Univ, Affiliated Hosp, Dept Hepatol, Jilin, Jilin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Ma, Zhenhua,Wang, Xiaomei,Yin, Peiyuan,et al. Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury[J]. MEDICINE,2019,98(31):11.
APA Ma, Zhenhua.,Wang, Xiaomei.,Yin, Peiyuan.,Wu, Ruihong.,Zhou, Lina.,...&Niu, Junqi.(2019).Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury.MEDICINE,98(31),11.
MLA Ma, Zhenhua,et al."Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury".MEDICINE 98.31(2019):11.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ma, Zhenhua]'s Articles
[Wang, Xiaomei]'s Articles
[Yin, Peiyuan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ma, Zhenhua]'s Articles
[Wang, Xiaomei]'s Articles
[Yin, Peiyuan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ma, Zhenhua]'s Articles
[Wang, Xiaomei]'s Articles
[Yin, Peiyuan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.