DICP OpenIR
Challenges and Advances in the Fabrication of Monolithic Bioseparation Materials and their Applications in Proteomics Research
Ma, Shujuan1; Li, Ya1; Ma, Chen1; Wang, Yan1; Ou, Junjie1,2; Ye, Mingliang1,2
Corresponding AuthorOu, Junjie(junjieou@dicp.ac.cn)
Keywordaffinity chromatography bioseparation glycoproteomics hybrid monoliths monolithic materials phosphoproteomics
Source PublicationADVANCED MATERIALS
2019-09-10
ISSN0935-9648
DOI10.1002/adma.201902023
Pages27
Funding ProjectChina State Key Basic Research Program[2017YFA0505004] ; China State Key Basic Research Program[2016YFA0501402] ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS)[DICP TMSR201601] ; National Natural Sciences Foundation of China[21575141] ; CAS-Weigao Research & Development Program[[2017]-009]
Funding OrganizationChina State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; POROUS POLYMER MONOLITHS ; POLYHEDRAL OLIGOMERIC SILSESQUIOXANE ; POLAR STATIONARY PHASES ; ONE-POT PREPARATION ; LARGE SURFACE-AREA ; LECTIN AFFINITY-CHROMATOGRAPHY ; HIGHLY EFFICIENT SEPARATION ; IMMOBILIZED ENZYME REACTORS ; ENE CLICK REACTION
AbstractHigh-performance liquid chromatography integrated with tandem mass spectrometry (HPLC-MS/MS) has become a powerful technique for proteomics research. Its performance heavily depends on the separation efficiency of HPLC, which in turn depends on the chromatographic material. As the "heart" of the HPLC system, the chromatographic material is required to achieve excellent column efficiency and fast analysis. Monolithic materials, fabricated as continuous supports with interconnected skeletal structure and flow-through pores, are regarded as an alternative to particle-packed columns. Such materials are featured with easy preparation, fast mass transfer, high porosity, low back pressure, and miniaturization, and are next-generation separation materials for high-throughput proteins and peptides analysis. Herein, the recent progress regarding the fabrication of various monolithic materials is reviewed. Special emphasis is placed on studies of the fabrication of monolithic capillary columns and their applications in separation of biomolecules by capillary liquid chromatography (cLC). The applications of monolithic materials in the digestion, enrichment, and separation of phosphopeptides and glycopeptides from biological samples are also considered. Finally, advances in comprehensive 2D HPLC separations using monolithic columns are also shown.
Language英语
Funding OrganizationChina State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program ; China State Key Basic Research Program ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP, CAS) ; National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program
WOS IDWOS:000486129600001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/173027
Collection中国科学院大连化学物理研究所
Corresponding AuthorOu, Junjie
Affiliation1.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ma, Shujuan,Li, Ya,Ma, Chen,et al. Challenges and Advances in the Fabrication of Monolithic Bioseparation Materials and their Applications in Proteomics Research[J]. ADVANCED MATERIALS,2019:27.
APA Ma, Shujuan,Li, Ya,Ma, Chen,Wang, Yan,Ou, Junjie,&Ye, Mingliang.(2019).Challenges and Advances in the Fabrication of Monolithic Bioseparation Materials and their Applications in Proteomics Research.ADVANCED MATERIALS,27.
MLA Ma, Shujuan,et al."Challenges and Advances in the Fabrication of Monolithic Bioseparation Materials and their Applications in Proteomics Research".ADVANCED MATERIALS (2019):27.
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