DICP OpenIR
Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism
Ren, Xiaoqian1,2; Geng, Ningbo1; Zhang, Haijun1; Wang, Feidi3; Gong, Yufeng1; Song, Xiaoyao1; Luo, Yun1,2; Zhang, Baoqin1; Chen, Jiping1
Corresponding AuthorZhang, Haijun(hjzhang@dicp.ac.cn)
KeywordChlorinated paraffins HepG2 cell Cytotoxicity Metabolomics
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
2019-10-01
ISSN0048-9697
DOI10.1016/j.scitotenv.2019.05.388
Volume685Pages:297-307
Funding ProjectChinese National Basic Research Program[2015CB453100] ; National Natural Science Foundation of China[21337002] ; National Natural Science Foundation of China[21607152] ; National Natural Science Foundation of China[21707140]
Funding OrganizationChinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS SubjectEnvironmental Sciences
WOS Research AreaEnvironmental Sciences & Ecology
WOS KeywordBISPHENOL-A ; METABOLOMICS ; MECHANISM ; RESPONSES ; EXPOSURE ; RATS ; ACTIVATION ; CARNITINE ; TOXICITY ; LENGTH
AbstractWith the phasing out of short-chain chlorinated paraffins (SCCPs), the production and emissions of medium- and long-chain chlorinated paraffins (MCCPs and LCCPs) are expected to increase. In this study, cell viability assay and pseudotargeted metabolomics approach were adopted to define and compare the toxic effects induced by SCCPs, MCCPs and LCCPs. The dose response curves indicated that three CP mixtures with comparable chlorine contents produced similar inhibitory effects on cell viability. At exposure concentration of 100 mu g/L, three CP mixtures all induced significant increases in levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and a significant reduction in level of adenosine triphosphate production (ATP), and produced similar impact intensities on overall metabolism. A stronger perturbation in phospholipid and fatty add metabolism was observed in all CP exposure groups. In comparison with SCCPs and MCCPs, LCCPs produced a stronger suppressive effect on amino acid transport across cell membrane and induced an opposite effect on purine metabolism. Furthermore, the toxicity mechanism and possible health risks of the three types of CPs were discussed. MCCPs shared the most similar cytotoxicity and metabolic perturbation with SCCPs, suggesting that there should be concern about using MCCPs as alternatives to SCCPs. (C) 2019 Published by Elsevier B.V.
Language英语
Funding OrganizationChinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese National Basic Research Program ; Chinese National Basic Research Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS IDWOS:000477951900027
PublisherELSEVIER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/173919
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang, Haijun
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Ren, Xiaoqian,Geng, Ningbo,Zhang, Haijun,et al. Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,685:297-307.
APA Ren, Xiaoqian.,Geng, Ningbo.,Zhang, Haijun.,Wang, Feidi.,Gong, Yufeng.,...&Chen, Jiping.(2019).Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism.SCIENCE OF THE TOTAL ENVIRONMENT,685,297-307.
MLA Ren, Xiaoqian,et al."Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism".SCIENCE OF THE TOTAL ENVIRONMENT 685(2019):297-307.
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