DICP OpenIR
Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma
He, Hui1; Chen, Di2; Cui, Shimeng3; Piao, Hailong2; Tang, Haibo1; Wang, Xun1; Ye, Peng4; Jin, Shi1
Corresponding AuthorJin, Shi(jinshi_1969@hotmail.com)
KeywordlncRNA ceRNA network HCC OIP5-AS1 topological analysis
Source PublicationONCOLOGY REPORTS
2019-08-01
ISSN1021-335X
DOI10.3892/or.2019.7181
Volume42Issue:2Pages:745-752
Funding ProjectNational Natural Science Foundation of China[NSFC 81702526]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS SubjectOncology
WOS Research AreaOncology
WOS KeywordPROGNOSTIC MARKERS ; CERNA ; MICRORNAS ; LNCRNA ; CHEMOPREVENTION ; PROLIFERATION ; EXPRESSION ; SPONGES ; OBESITY ; CANCER
AbstractThe present study was designed to identify the endogenous RNA regulatory networks involved in hepatocellular carcinoma (HCC) by bioinformatic analysis. Both miRNA interaction network-based correlation analysis and expression-based Spearman correlation coefficients were utilized to identify potential mRNA-lncRNA interactions. Then, a competitive endogenous (ce)RNA network was constructed from these interactions, and network topology and Gene Ontology enrichment analyses were conducted to mine potential functions of ceRNAs. In HCC samples, a ceRNA network was constructed. It was composed of 35,657 edges connecting 113 lncRNAs and 6,136 mRNAs which were differentially expressed in HCC and normal liver tissues. Meanwhile, a number of significantly positively correlated mRNA and lncRNA pairs in this ceRNA network were found to be consistently positively correlated in another independent dataset. To be noted, further analyses on the potential roles of ceRNAs demonstrated than various lncRNAs such as LINC00657, TUG1 and SNHG1 may play key roles in HCC by regulating protein phosphorylation or cell cycle pathways or influencing miRNAs. From the perspective that lncRNAs can function as ceRNAs, this study revealed that the interaction between lncRNAs, miRNAs and mRNAs may provide new insight for the diagnosis and treatment in the tumorigenesis of hepatocellular carcinoma.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS IDWOS:000475611600024
PublisherSPANDIDOS PUBL LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/173955
Collection中国科学院大连化学物理研究所
Corresponding AuthorJin, Shi
Affiliation1.Dalian Med Univ, Affiliated Hosp 1, Dept Laparoscop Surg, 193 Lianhe Rd, Dalian 116000, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Dalian 116000, Liaoning, Peoples R China
4.Liaoning Canc Hosp & Inst, Dept Urol Surg, Shenyang 110042, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
He, Hui,Chen, Di,Cui, Shimeng,et al. Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma[J]. ONCOLOGY REPORTS,2019,42(2):745-752.
APA He, Hui.,Chen, Di.,Cui, Shimeng.,Piao, Hailong.,Tang, Haibo.,...&Jin, Shi.(2019).Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma.ONCOLOGY REPORTS,42(2),745-752.
MLA He, Hui,et al."Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma".ONCOLOGY REPORTS 42.2(2019):745-752.
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