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Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum
Shen, Li1,2,3,4; Ai, Chun-Zhi5; Song, Yong-Chun3; Wang, Feng-Wu3; Jiao, Rui-Hua3; Zhang, Ai-Hua3; Man, Hui-Zi6; Tan, Ren-Xiang3
Corresponding AuthorShen, Li(shenli@yzu.edu.cn)
Source PublicationJOURNAL OF NATURAL PRODUCTS
2019-06-01
ISSN0163-3864
DOI10.1021/acs.jnatprod.8b01034
Volume82Issue:6Pages:1503-1509
Funding ProjectNational Natural Science Foundation of China[21372191] ; National Natural Science Foundation of China[81121062] ; National Natural Science Foundation of China[21132004] ; National Natural Science Foundation of China[21072092]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS KeywordMACROCYCLIC TRICHOTHECENES ; CHEMICAL MODIFICATION ; VERRUCARIN-A ; DERIVATIVES
AbstractSix new macrolides named myrothecines D-G (1-4), 16-hydroxymytoxin B (5), and 14'-dehydrovertisporin (6), including four 10,13-cyclotrichothecane derivatives, in addition to 12 known compounds (7-18), were isolated from three endophytic Myrothecium roridum, IFB-E008, IFB-E009, and IFB-E012. The isolated compounds were characterized by MS, NMR, CD, and single-crystal X-ray crystallography. The isolated macrolides exhibited an antiproliferation effect against chronic myeloid leukemia K562 and colorectal carcinoma SW1116 cell lines. Compounds 1-6 were cytotoxic, with IC50 values ranging between 56 nM and 16 mu M. Since slight structural changes led to obvious activity differences, the CoMFA (comparative analysis) and CoMSIA (comparative molecular similarity indices analysis) methods were then used to explore the 3D QSAR (three-dimensional quantitative structure activity relationship) of these macrolides. The result showed that the steric, electrostatic, hydrophobic, and H-bond acceptor factors were involved in their cytotoxicity and provided an in-depth understanding of the structure activity relationships of these metabolites.
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS IDWOS:000473827300013
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/175247
Collection中国科学院大连化学物理研究所
Corresponding AuthorShen, Li
Affiliation1.Yangzhou Univ, Med Coll, Inst Translat Med, Yangzhou 225001, Jiangsu, Peoples R China
2.Yangzhou Univ, Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China
3.Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
4.Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China
5.Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Inst Adv Study,Lab Optoelect Devices & Syst, Shenzhen 518061, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Shen, Li,Ai, Chun-Zhi,Song, Yong-Chun,et al. Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(6):1503-1509.
APA Shen, Li.,Ai, Chun-Zhi.,Song, Yong-Chun.,Wang, Feng-Wu.,Jiao, Rui-Hua.,...&Tan, Ren-Xiang.(2019).Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum.JOURNAL OF NATURAL PRODUCTS,82(6),1503-1509.
MLA Shen, Li,et al."Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum".JOURNAL OF NATURAL PRODUCTS 82.6(2019):1503-1509.
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