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题名: The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity
作者: Liu, Y;  Li, W;  Li, P;  Deng, MC;  Yang, SL;  Yang, L
关键词: ginseng-drug interaction ;  intestinal bacterial metabolite ;  ginsenoside ;  CYP3A
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2004-10-01
卷: 27, 期:10, 页:1555-1560
收录类别: SCI
文章类型: Article
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: The intestinal bacterial metabolites of ginsenosides are responsible for the main pharmacological activities of ginseng. The purpose of this study was to find whether these metabolites influence hepatic metabolic enzymes and to predict the potential for ginseng-prescription drug interactions. Utilizing the probe reaction of CYP3A activity, testosterone 6beta-hydroxylation, the effects of derivatives of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol families on CYP3A activity in rat liver microsomes were assayed. Our results showed that ginsenosides from the 20(S)-protopanaxadiol and 20(S)-protopanaxatriol family including Rb-1, Rb-2, Rc, Compound-K, Re, and Rg(1), had no inhibitory effect, whereas Rg(2), 20(S)-panaxatriol and 20(S)-protopanaxatriol exhibited competitive inhibitory activity against CVP3A activity in these microsomes with the inhibition constants (K) of 86.4+/-0.8mum, 1.7+/-0.1mum, and 3.2+/-0.2 mum, respectively. This finding demonstrates that differences in their chemical structure might influence the effects of ginsenosides on CYP3A activity and that ginseng-derived products might have potential for significant ginseng-drug interactions.
关键词[WOS]: IN-VITRO ;  DRUG-INTERACTIONS ;  LIVER-MICROSOMES ;  GINSENG SAPONINS ;  RAT-LIVER ;  CYTOCHROME-P450 ;  ABSORPTION ;  EXCRETION ;  TOXICITY ;  ENZYMES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000224522100013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/80971
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Dalian 116023, Peoples R China

Recommended Citation:
Liu, Y,Li, W,Li, P,et al. The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2004,27(10):1555-1560.
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