DICP OpenIR
Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
Zhang, XZ; Liang, XM; Xiao, HB; Xu, Q
Source PublicationJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
2004-02-01
DOI10.1016/j.jasms.2003.09.014
Volume15Issue:2Pages:180-187
Indexed BySCI
SubtypeArticle
Funding Project1804
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Analytical ; Chemistry, Physical ; Spectroscopy
WOS Research AreaChemistry ; Spectroscopy
WOS KeywordCENTRIFUGAL PARTITION CHROMATOGRAPHY ; PREPARATIVE SEPARATION ; ARRAY DETECTION
AbstractThe applicability of on-line coupling of reversed-phase high-performance liquid chromatography to atmospheric pressure ionization tandem mass spectrometry for the separation and characterization of hop acids mixture from the crude extract of Humulus lupulus was investigated. The solvent system consisting of acetonitrile-aqueous formic acid was used to give proper separation of the six main hop bitter acids within 30 min. Further structural information about the components was acquired by collision-induced dissociation (CID). On the basis of analyses of the fragmentation patterns of the major alpha- and beta-bitter acids respectively, identification of the minor ones was performed using selected reaction monitoring (SRM) with a group of qualitatively relevant selected precursor-product ion transitions for each bitter acid in a single high performance liquid chromatography (HPLC) run. Using this technique, six minor hop acids, including "adprelupulone" observed for the first time in natural resources, were detected along with the six major acids. This hyphenated techniques provides potency for rapid qualitative determination of analogs and homologs in mixtures. (C) 2004 American Society for Mass Spectrometry.
Language英语
URL查看原文
WOS IDWOS:000188825600006
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/81491
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Grp Pharmaceut Chem, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Zhang, XZ,Liang, XM,Xiao, HB,et al. Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2004,15(2):180-187.
APA Zhang, XZ,Liang, XM,Xiao, HB,&Xu, Q.(2004).Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,15(2),180-187.
MLA Zhang, XZ,et al."Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry".JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 15.2(2004):180-187.
Files in This Item:
File Name/Size DocType Version Access License
20041H8Q14635L.pdf(203KB) 开放获取--Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, XZ]'s Articles
[Liang, XM]'s Articles
[Xiao, HB]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, XZ]'s Articles
[Liang, XM]'s Articles
[Xiao, HB]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, XZ]'s Articles
[Liang, XM]'s Articles
[Xiao, HB]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.