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Discrimination of Type 2 diabetic patients from healthy controls by using metabonomics method based on their serum fatty acid profiles
Yang, J; Xu, GW; Hong, QF; Liebich, HM; Lutz, K; Schmulling, RM; Wahl, HG
关键词Pattern Recognition Diabetes Mellitus Fatty Acid Profiles Linear Discriminant Analysis Artificial Neural Networks Metabonomics
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2004-12-25
DOI10.1016/j.jchromb.2004.09.023
813期:1-2页:53-58
收录类别SCI
文章类型Article
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]FUNCTIONAL GENOMICS ; NEURAL NETWORKS ; MELLITUS ; LIPIDS
英文摘要Metabonomics, the study of metabolites and their roles in various disease states, is a novel methodology arising from the post-genomics era. This methodology has been applied in many fields, including work in cardiovascular research and drug toxicology. In this study, metabonomics method was employed to the diagnosis of Type 2 diabetes mellitus (DM2) based on serum lipid metabolites. The results suggested that serum fatty acid profiles determined by capillary gas chromatography combined with pattern recognition analysis of the data might provide an effective approach to the discrimination of Type 2 diabetic patients from healthy controls. And the applications of pattern recognition methods have improved the sensitivity and specificity greatly. (C) 2004 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000225413200005
引用统计
被引频次:92[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/81603
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, Dalian 116011, Peoples R China
2.Univ Tubingen, Med Klin, Zent Lab, D-72076 Tubingen, Germany
3.Klinikum FUlda, Inst Lab Med, D-36043 Fulda, Germany
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GB/T 7714
Yang, J,Xu, GW,Hong, QF,et al. Discrimination of Type 2 diabetic patients from healthy controls by using metabonomics method based on their serum fatty acid profiles[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2004,813(1-2):53-58.
APA Yang, J.,Xu, GW.,Hong, QF.,Liebich, HM.,Lutz, K.,...&Wahl, HG.(2004).Discrimination of Type 2 diabetic patients from healthy controls by using metabonomics method based on their serum fatty acid profiles.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,813(1-2),53-58.
MLA Yang, J,et al."Discrimination of Type 2 diabetic patients from healthy controls by using metabonomics method based on their serum fatty acid profiles".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 813.1-2(2004):53-58.
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