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题名: Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients
作者: Xu, GW;  Yao, QH;  Weng, QF;  Su, BL;  Zhang, X;  Xiong, JH
关键词: oxidative DNA damage ;  8-hydroxydeoxyguanosine ;  diabetic nephropathy
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2004-09-21
DOI: 10.1016/j.jpba.2004.04.016
卷: 36, 期:1, 页:101-104
收录类别: SCI
文章类型: Article
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Increased oxidative stress induced by hyperglycemia may contribute to the pathogenesis of diabetic complications. Urinary 8-hydroxydeoxyguanosine (8-OHdG) has been reported to serve as a sensitive biomarker of oxidative DNA damage and also of oxidative stress. This article studied oxidative DNA damage in patients with diabetic nephropathy and in healthy control subjects by urinary 8-OHdG evaluations. Contents of 8-OHdG in urine were analyzed by capillary electrophoresis with end-column amperometric detection (CE-AD) after a single-step solid-phase extraction (SPE). Levels of urinary 8-OHdG in diabetic nephropathy patients with macroalbuminuria was significant higher than in control subjects (5.72 +/- 6.89 mumol/mol creatinine versus 2.33 +/- 2.83 mumol/mol creatinine, P = 0.018). A significant difference of 24 h urinary 8-OHdG excretions exists between the patients with macroalbuminuria and the patients with nonnoalbuminuria (19.2 +/- 16.8 mug/24 h versus 8.1 +/- 1.7 mug/24 h, P = 0.015). There was a positive correlation between urinary excretion of 8-OHdG and glycosylated hemoglobin (HbA(1)c) (r = 0.287, P = 0.022). A weak correlation exists between the levels of 8-OHdG and triglyceride (r = 0.230, P = 0.074). However, the urinary 8-OHdG contents are not correlated with blood pressure and total cholesterol. The increased excretion of urinary 8-OHdG is seen as indicating an increased systemic level of oxidative DNA damage in diabetic nephropathy patients. (C) 2004 Elsevier B.V. All rights reserved.
关键词[WOS]: COLUMN AMPEROMETRIC DETECTION ;  DYNAMIC PH JUNCTION ;  CAPILLARY-ELECTROPHORESIS ;  ELECTROCHEMICAL DETECTION ;  STRESS ;  COMPLICATIONS ;  MELLITUS ;  8-HYDROXY-2'-DEOXYGUANOSINE ;  HYPERGLYCEMIA ;  EXCRETION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000224328000013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/81605
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&D Ctr, Dalian 116011, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China

Recommended Citation:
Xu, GW,Yao, QH,Weng, QF,et al. Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2004,36(1):101-104.
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