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题名: Comparison of the shape parameters of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes
作者: Sun, Y;  Yu, XJ;  Takaoka, Y;  Oh-I, SI;  Duzgunes, N;  Hirota, S
关键词: shape parameter ;  DNA ;  rheological behavior ;  lipoplexes ;  viscosity ;  polyanion solutions
刊名: JOURNAL OF COLLOID AND INTERFACE SCIENCE
发表日期: 2004-08-15
DOI: 10.1016/j.jcis.2004.03.064
卷: 276, 期:2, 页:317-322
收录类别: SCI
文章类型: Article
项目归属: 1816
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: In this study, we used a rheological method to study the shape of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes. We introduced two kinds of anionic polyelectrolytes, sodium polygalacturonate (PGU) and sodium dextran sulfate (DSS), of varying size, as models for DNA. The prepared complexes were incubated under laminar flow conditions. The results show the same quantitative relation between the shape parameter of lipoplexes and the length of anionic polyelectrolytes, including DNA. The rheological behavior of PGU and DSS were similar to that of DNA. (C) 2004 Elsevier Inc. All rights reserved.
关键词[WOS]: GENE-TRANSFER ;  LIPOSOME COMPLEXES ;  TRANSFECTION ;  LIPOPLEXES ;  MORPHOLOGY ;  EXPRESSION ;  DELIVERY ;  CELLS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000223006200008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/81925
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Pacific, Sch Dent, Dept Microbiol, San Francisco, CA 94115 USA
3.Tokyo Denki Univ, Chigasaki, Kanagawa 2530054, Japan

Recommended Citation:
Sun, Y,Yu, XJ,Takaoka, Y,et al. Comparison of the shape parameters of DNA-cationic lipid complexes and model polyelectrolyte-lipid complexes[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2004,276(2):317-322.
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