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Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis
Xu, F; Sun, LX; Tan, ZC; Liang, HG; Li, RL
KeywordIbuprofen Adiabatic Calorimeter Heat Capacity Thermodynamic Function Dsc Tg-dtg
Source PublicationTHERMOCHIMICA ACTA
2004-03-23
DOI10.1016/j.tca.2003.08.021
Volume412Issue:1-2Pages:33-37
Indexed BySCI
SubtypeArticle
Funding Project1504
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical ; Chemistry, Physical
WOS Research AreaChemistry
WOS KeywordTEMPERATURE HEAT-CAPACITY ; MIXTURES ; ENTHALPY ; ACID
AbstractMolar heat capacities of ibuprofen were precisely measured with a small sample precision automated adiabatic calorimeter over the temperature range from 80 to 400 K. The polynomial functions of C-p,C-m (J K-1 mol(-1)) versus T were established on the heat capacity measurements by means of the least fitting square method. The functions are as follows: for solid ibuprofen, at the temperature range of 79.105 K less than or equal to T less than or equal to 333.297 K, C-p,C-m = 144.27 + 77.046X + 3.5171X(2) + 10.925X(3) + 11.224X(4), where X = (T - 206.201)/127.096; for liquid ibuprofen, at the temperature range of 353.406 K less than or equal to T less than or equal to 378.785 K, C-p,C-m = 325.79 + 8.9696X - 1.6073X(2) - 1.5145 X-3, where X = (T - 366.095)/12.690. A fusion transition at T = 348.02 K was found from the C-p-T curve. The molar enthalpy and entropy of the fusion transition were determined to be 26.65 kJ mol(-1) and 76.58 J mol(-1) K-1, respectively. The thermodynamic functions on the base of the reference temperature of 298.15 K, (H-T - H-298.15) and (S-T - S-298.15), were derived. Thermal characteristic of ibuprofen was studied by thermo-gravimetric analysis (TG-DTG) and differential scanning calorimeter (DSC). The temperature of fusion, the molar enthalpy and entropy of fusion obtained by DSC were well consistent with those obtained by adiabatic calorimeter. The evaporation process of ibuprofen was investigated further by TG and DTG, and the activation energy of the evaporation process was determined to be 80.3 +/- 1.4 kJ mol(-1). (C) 2003 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000220132200005
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/81935
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Thermochem Lab, Dalian 116023, Peoples R China
2.Hunan Inst Drug Detect, Changsha 410001, Peoples R China
Recommended Citation
GB/T 7714
Xu, F,Sun, LX,Tan, ZC,et al. Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis[J]. THERMOCHIMICA ACTA,2004,412(1-2):33-37.
APA Xu, F,Sun, LX,Tan, ZC,Liang, HG,&Li, RL.(2004).Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis.THERMOCHIMICA ACTA,412(1-2),33-37.
MLA Xu, F,et al."Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis".THERMOCHIMICA ACTA 412.1-2(2004):33-37.
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