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题名: Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis
作者: Xu, F;  Sun, LX;  Tan, ZC;  Liang, HG;  Li, RL
关键词: ibuprofen ;  adiabatic calorimeter ;  heat capacity ;  thermodynamic function ;  DSC ;  TG-DTG
刊名: THERMOCHIMICA ACTA
发表日期: 2004-03-23
DOI: 10.1016/j.tca.2003.08.021
卷: 412, 期:1-2, 页:33-37
收录类别: SCI
文章类型: Article
项目归属: 1504
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical ;  Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: Molar heat capacities of ibuprofen were precisely measured with a small sample precision automated adiabatic calorimeter over the temperature range from 80 to 400 K. The polynomial functions of C-p,C-m (J K-1 mol(-1)) versus T were established on the heat capacity measurements by means of the least fitting square method. The functions are as follows: for solid ibuprofen, at the temperature range of 79.105 K less than or equal to T less than or equal to 333.297 K, C-p,C-m = 144.27 + 77.046X + 3.5171X(2) + 10.925X(3) + 11.224X(4), where X = (T - 206.201)/127.096; for liquid ibuprofen, at the temperature range of 353.406 K less than or equal to T less than or equal to 378.785 K, C-p,C-m = 325.79 + 8.9696X - 1.6073X(2) - 1.5145 X-3, where X = (T - 366.095)/12.690. A fusion transition at T = 348.02 K was found from the C-p-T curve. The molar enthalpy and entropy of the fusion transition were determined to be 26.65 kJ mol(-1) and 76.58 J mol(-1) K-1, respectively. The thermodynamic functions on the base of the reference temperature of 298.15 K, (H-T - H-298.15) and (S-T - S-298.15), were derived. Thermal characteristic of ibuprofen was studied by thermo-gravimetric analysis (TG-DTG) and differential scanning calorimeter (DSC). The temperature of fusion, the molar enthalpy and entropy of fusion obtained by DSC were well consistent with those obtained by adiabatic calorimeter. The evaporation process of ibuprofen was investigated further by TG and DTG, and the activation energy of the evaporation process was determined to be 80.3 +/- 1.4 kJ mol(-1). (C) 2003 Elsevier B.V. All rights reserved.
关键词[WOS]: TEMPERATURE HEAT-CAPACITY ;  MIXTURES ;  ENTHALPY ;  ACID
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000220132200005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/81935
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Thermochem Lab, Dalian 116023, Peoples R China
2.Hunan Inst Drug Detect, Changsha 410001, Peoples R China

Recommended Citation:
Xu, F,Sun, LX,Tan, ZC,et al. Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis[J]. THERMOCHIMICA ACTA,2004,412(1-2):33-37.
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