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Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology
Liu, XD; Xue, WM; Liu, Q; Yu, WT; Fu, YL; Xiong, X; Ma, XJ; Yuan, Q
关键词Swelling Behaviour Alginate-chitosan Microcapsule External Gelation Internal Gelation
刊名CARBOHYDRATE POLYMERS
2004-07-15
DOI10.1016/j.carbpol.2004.03.011
56期:4页:459-464
收录类别SCI
文章类型Article
项目归属1802
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]DELIVERY ; BEADS ; RELEASE
英文摘要Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (S-w) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low S-w. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that S-w of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope. (C) 2004 Elsevier Ltd. All rights reserved.
语种英语
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WOS记录号WOS:000222747100008
引用统计
被引频次:72[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/81965
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
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GB/T 7714
Liu, XD,Xue, WM,Liu, Q,et al. Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology[J]. CARBOHYDRATE POLYMERS,2004,56(4):459-464.
APA Liu, XD.,Xue, WM.,Liu, Q.,Yu, WT.,Fu, YL.,...&Yuan, Q.(2004).Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology.CARBOHYDRATE POLYMERS,56(4),459-464.
MLA Liu, XD,et al."Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology".CARBOHYDRATE POLYMERS 56.4(2004):459-464.
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