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题名: Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology
作者: Liu, XD;  Xue, WM;  Liu, Q;  Yu, WT;  Fu, YL;  Xiong, X;  Ma, XJ;  Yuan, Q
关键词: swelling behaviour ;  alginate-chitosan microcapsule ;  external gelation ;  internal gelation
刊名: CARBOHYDRATE POLYMERS
发表日期: 2004-07-15
DOI: 10.1016/j.carbpol.2004.03.011
卷: 56, 期:4, 页:459-464
收录类别: SCI
文章类型: Article
项目归属: 1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (S-w) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low S-w. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that S-w of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope. (C) 2004 Elsevier Ltd. All rights reserved.
关键词[WOS]: DELIVERY ;  BEADS ;  RELEASE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000222747100008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/81965
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China

Recommended Citation:
Liu, XD,Xue, WM,Liu, Q,et al. Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology[J]. CARBOHYDRATE POLYMERS,2004,56(4):459-464.
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