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题名: Synthesis of chiral stationary phases with radical polymerization reaction of cellulose phenylcarbamate derivatives and vinylized silica gel
作者: Chen, XM;  Qin, F;  Liu, YQ;  Huang, XD;  Zou, HF
关键词: chiral stationary phases, LC ;  radical polymerization ;  methacryloyl chloride ;  gamma-(trimethoxysilyl)propyl methacrylate
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2004-04-23
DOI: 10.1016/j.chroma.2004.02.007
卷: 1034, 期:1-2, 页:109-116
收录类别: SCI
文章类型: Article
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Cellulose phenylcarbamate derivatives having methacrylate groups were synthesized with regioselective and non-regioselective procedures. These derivatives were chemically immobilized onto a vinylized silica gel, respectively, via a radical co-polymerization reaction. The immobilization was efficiently attained using a small amount of AIBN. The chiral recognition abilities of the prepared chiral stationary phases (CSPs) were evaluated by HPLC resolution of test enantiomers. It was observed that most of the enantiomers were completely resolved with markedly high column efficiency of 30,000-40,000 plates per metre for the eluted peaks. The effect of the amount of methacrylolyl chloride used for preparation on resolution was investigated. A direct comparison of the chiral recognition ability was made on the regioselectively and non-regioselectively prepared CSPs. In addition, the chemically bonded-type of CSPs were found to be relatively stable with addition of solvents such as tetrahydrofuran (THF) and chloroform into the mobile phase, which can lead to the dissolution of cellulose derivatives on the coated CSPs. Thus the choice of solvents used as the mobile phase is greatly extended and better resolution of several test enantiomers was observed on the prepared CSPs with THF and chloroform as a composition in the mobile phase. The batch-to-batch and run-to-run reproducibility was also discussed on the newly prepared CSPs. (C) 2004 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  POLYSACCHARIDE DERIVATIVES ;  RECOGNITION ABILITY ;  ENANTIOMERS ;  SEPARATION ;  HPLC
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000220576400011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/81981
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph Res, Dalian 116011, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Analysis Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Chen, XM,Qin, F,Liu, YQ,et al. Synthesis of chiral stationary phases with radical polymerization reaction of cellulose phenylcarbamate derivatives and vinylized silica gel[J]. JOURNAL OF CHROMATOGRAPHY A,2004,1034(1-2):109-116.
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