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题名: Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines
作者: Huang, XD;  Kong, LA;  Li, X;  Chen, XG;  Guo, M;  Zou, HF
关键词: reviews ;  screening ;  bioactive compounds
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2004-12-05
DOI: 10.1016/j.jchromb.2004.06.046
卷: 812, 期:1-2, 页:71-84
收录类别: SCI
文章类型: Review
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Traditional Chinese medicines (TCMs), due to their long time clinic test and reliable therapeutic efficacy, are attracting increased global attention served as excellent pools of bioactive compounds for the discovery of new drugs. However, hundreds or even thousands of components are usually contained in traditional Chinese medicines and only a few compounds are responsible for the pharmaceutical and/or toxic effects. The large numbers of other components in traditional Chinese medicines make the screening and analysis of the bioactive components extremely difficult. By the way, the combination effect of bioactive components on the pharmacological activity makes it very difficult to clear the therapeutic mechanism of TCMs. Therefore, some strategies have to design for screening of bioactive compounds in traditional Chinese medicines, which further leads to disclose the therapeutic mechanism of TCMs in molecular level. The review will summarize the present state of the art of screening strategy for active compounds in traditional Chinese medicines, and the chromatography methods for screening and analysis of bioactive compounds in traditional Chinese medicines will be emphasized. (C) 2004 Elsevier B.V. All rights reserved.
关键词[WOS]: HUMAN SERUM-ALBUMIN ;  PERFORMANCE LIQUID-CHROMATOGRAPHY ;  BIOLOGICALLY-ACTIVE COMPOUNDS ;  PHARMACOLOGICAL TESTING METHOD ;  AFFINITY-CHROMATOGRAPHY ;  STATIONARY-PHASE ;  BIOMEMBRANE CHROMATOGRAPHY ;  MOLECULAR BIOCHROMATOGRAPHY ;  ANGELICA-SINENSIS ;  HERBAL MEDICINES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000225410300006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/81991
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Huang, XD,Kong, LA,Li, X,et al. Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2004,812(1-2):71-84.
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