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题名: Study on conical columns for semi-preparative liquid chromatography
作者: Ma, JP;  Guan, YF;  Chen, LX
关键词: conical column ;  flow profile ;  zone shape ;  semi-preparative liquid chromatography
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2003-03-01
卷: 26, 期:3-4, 页:307-312
收录类别: SCI
文章类型: Article
部门归属: 105
项目归属: 105
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: The dynamic flow profiles and column efficiencies in conically shaped semi-preparative liquid chromatographic columns (inlet ID larger than outlet ID) with two different conical angles (7degrees and 15degrees) were studied. The dynamic flow profiles were studied by an on-column visualization method. Conical columns were compared with cylindrical column of the same length and internal volume. The results showed that the flow profile of a sample band in the conical column of 7degrees (50 mm x 17 mm --> 11 mm ID) was parabolic in shape. The sample band migrated slower in the wall region than in the central region, as in the cylindrical column (50 mm x 14 mm ID). However, the sample band in the conical column of 15degrees (50 mm x 20 mm --> 7 mm ID) migrated slower in the central region than in the wall region, resulting in a reverse parabolic flow profile, in contrast to that in cylindrical column. This indicated that a flat flow profile might be realized in a conical column with a conical angle between 7degrees and 15degrees. The conical column of 15degrees had the highest column efficiency among the three columns under the same conditions. Compared with the cylindrical column packed with identical packing material, the conical column of 15degrees had 22%-45% higher column efficiency and 11%-27% higher peak height.
关键词[WOS]: SOLUTE MIGRATION ;  VISUALIZATION ;  DIAMETER
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000181950200014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/82153
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Analyt Chem & Micro Instrumentat, Dalian 116012, Peoples R China
2.Liaoning Univ Petr & Chem Technol, Dept Appl Chem, Fushun 113001, Peoples R China

Recommended Citation:
Ma, JP,Guan, YF,Chen, LX. Study on conical columns for semi-preparative liquid chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2003,26(3-4):307-312.
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