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Synthesis of novel ferrocenylphosphine-amidine ligands with central and planar chirality and their diastereomeric effect in Pd-catalyzed asymmetric allylic alkylation
Hu, XP; Chen, HL; Dai, HC; Hu, XQ; Zheng, Z
Source PublicationTETRAHEDRON-ASYMMETRY
2003-07-18
DOI10.1016/S0957-4166(03)00437-3
Volume14Issue:14Pages:2073-2080
Indexed BySCI ; IC
SubtypeArticle
Department206
Funding Project206
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical
WOS Research AreaChemistry
WOS Keyword2'-SUBSTITUTED 1,1'-P,N-FERROCENE LIGANDS ; TRANSITION-METAL-COMPLEXES ; ALPHA-AMINO-ACIDS ; ENANTIOSELECTIVE SYNTHESIS ; AMINOPHOSPHINE LIGANDS/ ; SUBSTITUTION-REACTIONS ; FERROCENE DERIVATIVES ; AROMATIC-ALDEHYDES ; EFFICIENT LIGANDS ; IMINE LIGANDS
AbstractSome novel ferrocenylphosphine-amidine ligands with central and planar chirality were prepared from (R,S-p)-PPFNH2-R 3 and its diastereomer (S,S-p)-PPFNH2 3a. The efficiency and diastereomeric impact of these ferrocenylphosphine-amidine ligands in the palladium-catalyzed asymmetric allylic substitution was examined, and up to 96% e.e. with 98% yield was achieved by the use of ligand (R,S-p)-4a with a methyl group in the amidino moiety. The results also indicated that (R)-central chirality and (S-p)-planar chirality in these ferrocenylphosphine-amidine ligands were matched for the palladium-catalyzed asymmetric allylic alkylation. (C) 2003 Elsevier Ltd. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000184259500019
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/82829
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Hu, XP,Chen, HL,Dai, HC,et al. Synthesis of novel ferrocenylphosphine-amidine ligands with central and planar chirality and their diastereomeric effect in Pd-catalyzed asymmetric allylic alkylation[J]. TETRAHEDRON-ASYMMETRY,2003,14(14):2073-2080.
APA Hu, XP,Chen, HL,Dai, HC,Hu, XQ,&Zheng, Z.(2003).Synthesis of novel ferrocenylphosphine-amidine ligands with central and planar chirality and their diastereomeric effect in Pd-catalyzed asymmetric allylic alkylation.TETRAHEDRON-ASYMMETRY,14(14),2073-2080.
MLA Hu, XP,et al."Synthesis of novel ferrocenylphosphine-amidine ligands with central and planar chirality and their diastereomeric effect in Pd-catalyzed asymmetric allylic alkylation".TETRAHEDRON-ASYMMETRY 14.14(2003):2073-2080.
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