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题名: Synthesis of monomethylated dioscin derivatives and their antitumor activities
作者: Li, M;  Han, XW;  Yu, B
关键词: dioscin ;  methylation ;  synthesis ;  antitumor
刊名: CARBOHYDRATE RESEARCH
发表日期: 2003-01-20
卷: 338, 期:2, 页:117-121
收录类别: SCI ;  IC
文章类型: Article
部门归属: 502
项目归属: 502
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Applied ;  Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: All possible eight monomethylated dioscin derivatives (1-8) were synthesized. Their inhibitory activities against P388 and A-549 cells were determined, and the results indicate that six of the eight hydroxyls of dioscin are the 'key polar groupings' for tumor inhibitory activities. (C) 2002 Elsevier Science Ltd. All rights reserved.
关键词[WOS]: GLYCOSAMINO GLYCAN STRUCTURE ;  HEPARIN-LIKE FRAGMENTS ;  N-ACETYLGLUCOSAMINYLTRANSFERASE-V ;  SOLANUM STEROIDAL GLYCOSIDES ;  DIOSGENYL SAPONINS ;  RECOGNITION ;  OLIGOSACCHARIDES ;  PENTASACCHARIDE ;  TETRASACCHARIDE ;  AGENTS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000180604800001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/82867
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalyst, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Li, M,Han, XW,Yu, B. Synthesis of monomethylated dioscin derivatives and their antitumor activities[J]. CARBOHYDRATE RESEARCH,2003,338(2):117-121.
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