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题名: The study on a PVC membrane electrode for gemfibrozil
作者: Xu, F;  Sun, LX;  Matsuda, N;  Okada, T;  Tan, ZC;  Liang, JG
关键词: gemfibrozil ;  ion selective electrode ;  orthogonal experimental design ;  quantitative determination
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2002-02-01
卷: 25, 期:2, 页:165-167
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: In this paper, a poly(vinyl chloride) (PVC) membrane electrode is prepared for gemfibrozil, 2, 2-dimethyl-5(2,5-xylyloxy) valeric acid, based on its ion pair complexes with hexadecyltrioctyl ammonium iodide (HTOA). The membrane composition of the electrode was optimized by using the sequential level elimination method for orthogonal experimental design. The electrode has a Nernstian response range from 2.5 X 10(-5) to 0.1 mol/l with an average slope of 55.3 mV/decade. The limit of detection is 7.1 X 10(-6) mol/l. The electrode responses were not affected by pH in the range 10.0-12.3. A Na2B4O7-Na2CO3 buffer of pH = 11.0 was selected as the background electrolyte solution for potentiometric measurements. The electrode was used for determining gemfibrozil in pharmaceutical preparations with satisfactory results.
关键词[WOS]: CHROMATOGRAPHIC DETERMINATION ;  PLASMA ;  METABOLITES ;  URINE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000173615100002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/83165
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Jinan Univ, Dept Chem, Guangzhou 510632, Peoples R China
3.Natl Inst Adv Ind Sci & Technol, Nanoarchitecton Res Ctr, Tsukuba, Ibaraki 3058565, Japan
4.Natl Inst Adv Ind Sci & Technol, Electrochem Energy Conver Lab, Tsukuba, Ibaraki 3058565, Japan
5.Human Inst Drug Detect, Changsha 410001, Peoples R China

Recommended Citation:
Xu, F,Sun, LX,Matsuda, N,et al. The study on a PVC membrane electrode for gemfibrozil[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2002,25(2):165-167.
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