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题名: Towards manipulation of post-biosynthetic events in secondary metabolism of plant cell cultures
作者: Zhang, W;  Curtin, C;  Franco, C
关键词: plant cell culture ;  post-biosynthetic events ;  biosynthesis ;  secondary metabolism anthocyanin ;  alkaloid
刊名: ENZYME AND MICROBIAL TECHNOLOGY
发表日期: 2002-05-27
卷: 30, 期:6, 页:688-696
收录类别: ISTP ;  SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
英文摘要: Plant cell cultures have been suggested as a feasible technology for the production of a myriad of plant-derived metabolites. However, commercial application of plant cell culture has met limited success with only a handful of metabolites produced at the pilot- and commercial-scales. To improve the production of secondary metabolites in plant cell cultures, efforts have been devoted predominantly to the optimization of biosynthetic pathways by both process and genetic engineering approaches. Given that secondary metabolism includes-the synthesis. metabolism and catabolism of endogenous compounds by the specialized proteins, this review intends to draw attention to the manipulation and optimization of post-biosynthetic events that follow the formation of core metabolite structures in biosynthetic pathways. These post-biosynthetic events-the chemical and enzymatic modifications, transport, storage/secretion and catabolism/degradation have been largely unexplored in the past. Potential areas are identified where further research is needed to answer fundamental questions that have implications for advanced bioprocess design. Anthocyanin production by plant cell cultures is used as a case study for this discussion, as it presents a good example of compounds for which there are extensive research publications but still no commercial bioprocess. It is perceived that research on post-biosynthetic processes may lead to future opportunities for significant advances in commercial plant cell cultures. (C) 2002 Elsevier Science Inc. All rights reserved.
关键词[WOS]: GLUTATHIONE S-TRANSFERASES ;  ALKALOID BIOSYNTHESIS ;  CATHARANTHUS-ROSEUS ;  SUSPENSION-CULTURES ;  IMMUNOCYTOCHEMICAL LOCALIZATION ;  TABERNAEMONTANA-DIVARICATA ;  ANTHOCYANIN SEQUESTRATION ;  ACYLATED ANTHOCYANIN ;  ARABIDOPSIS ENCODES ;  ISOLATED VACUOLES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000175961200002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/83203
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Flinders Univ S Australia, Sch Med, Cooperat Res Ctr Bioprod & Biotechnol, Bedford Pk, SA 5042, Australia
2.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China

Recommended Citation:
Zhang, W,Curtin, C,Franco, C. Towards manipulation of post-biosynthetic events in secondary metabolism of plant cell cultures[J]. ENZYME AND MICROBIAL TECHNOLOGY,2002,30(6):688-696.
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